The price of secrets: It's amazing, how much pain, death, and destruction could have been avoided had Ralph ever mentioned to Catherine Fisk & Maloy's letter. Had Catherine known Ralph new about her past, knew about her relationship with Antonio, knew about why she was trying to poison him, she would never have taken the arsenic so far (if at all), Antonio would never have come to Wisconsin, and he never would've died.
If Catherine had come clean with Antonio about his false memory of Amelia's death, maybe he would've left sooner or at least begun to heal a bit more.
On a side note, I have to say that I don't get Alice. Why would she hate herself so much? Was it because she hated that Catherine had to whore herself to give Alice a normal life?