ABC Proteins: From Bacteria to Man [Hardcover]

I Barry Holland (Editor), Susan P. C. Cole (Editor), Karl Kuchler (Editor), Christopher F. Higgins (Editor)

Book Description

Publication Date: January 6, 2003

ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated.

Key Features
* Phylogeny and Evoloution of ABC Transporters
* Fundamental Aspects of the Mechanism of Action of ABC Transporters
* Prokaryote ABC Transporters
* Non-Mammalian Transporters
* Multidrug Transporters
* ABC Transporters, Physiological Roles and Human Disease
* Full color throughout

Editorial Reviews

Review

"...the volume unquestionably succeeds overall as an in-depth survey of both the biology and the biochemistry of a ubiquitous and astonishingly diverse family of very complex enzymes. Every group with an interest in these proteins should own a copy."
-CELL (July 2003)
"The editors of ABC Proteins: From Bacteria to Man have valiantly attempted to encompass in this volume the entire scope of research on these proteins, from atomic-resolution structure to human genetic diseases, and from Escherichia coli to Homo sapiens and Arabidopsis thaliana...
What the book makes obvious is that nearly all ABC proteins are membrane localized, ATP dependent, primary active transporters...In addition to advances in our understanding of ABC transporter structure, several chapters in the book also describe progress that has been made in elcuidating the mechanisms of transport.
The volume unquestionably succeeds overall as an in-depth survey of both the biology and the biochemistry of a ubiquitous and astoundingly diverse family of very complex enzymes. Every group with an interest in these proteins should own a copy. Finally, this book makes a convincing case that many laboratories that may not yet suspect it will soon have a much more abiding interest in ABC proteins."

"...well organized and included beautifully clear color images and figures."
-E STREAMS (July 2003)

From the Back Cover

The first and definitive work on one of the largest families of proteins, the ABC proteins!

ATP-binding cassette (ABC) proteins exists in all living organisms and form one of the largest superfamilies. They are integral to almost every biological process and physiological system. Most are involved in the transport of an enormous variety of substances across cell membranes, from small ions to large polypeptides. Many of these proteins are of considerable medical importance. Mutations in several abc-genes lead to genetic diseases, such as cystic fibrosis, Tangier disease and adrenoleukodystrophy, while others play crucial roles in immune responses, cholesterol homeostasis, potassium transport and the regulation of insulin secretion. Yet other ABCs are of major significance in resistance to antibiotics and antifungals, to herbicides in plants, to antimalarial agents, and provide a serious obstacle to chemotherapy in man.

With the amount of information on this rapidly expanding group of proteins increasing exponentially, this book is essential for anyone trying to stay abreast of the latest findings in this area of research, as well as those with an interest in experimantal therapeutics, clinical and cell biology, molecular biology, biochemistry, protein chemistry, structural biology, cancer chemotherapy, genetics and microbiology.

Written by leading scientists in the field in an accessible style, and including full color throughout, this volume is set to become the gold standard for ABC proteins.

Key Features
* Phylogeny and Evoloution of ABC Transporters
* Fundamental Aspects of the Mechanism of Action of ABC Transporters
* Prokaryote ABC Transporters
* Non-Mammalian Transporters
* Multidrug Transporters
* ABC Transporters, Physiological Roles and Human Disease
* Full color throughout

See all Editorial Reviews

Product Details

• Hardcover: 530 pages
• Publisher: Academic Press; 1 edition (January 6, 2003)
• Language: English
• ISBN-10: 0123525519
• ISBN-13: 978-0123525512
• Product Dimensions: 10.3 x 8.7 x 1.5 inches
• Shipping Weight: 4.4 pounds
• Amazon Best Sellers Rank: #2,256,632 in Books (See Top 100 in Books)