The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer’s amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.
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cleaving aggrecan, human adamalysin, major sheddase, multidomain proteins with multiple functions, meltrin alpha, prodomain removal, meltrin beta, constitutive shedding, tumour necrosis factor alpha convertase, gene family encoding membrane proteins, native aggrecan, aggrecan catabolism, disintegrin loop, modular proteins capable, disintegrin domain, metalloproteinase with thrombospondin motifs, metalloprotease domain, ectodomain shedding, placental leucine aminopeptidase, gland expansion, aggrecanase activity, metalloprotease active site, active metalloprotease, bovine dermatosparaxis, constitutive cleavage Key Phrases - Capitalized Phrases (CAPs): (learn more)
Biol Chem, Cell Biol, Cell Sci, Proc Natl Acad Sci, Der Biol, Cancer Res, Genes Der, Exp Cell Res, New York, Arthritis Rheum, Family of Proteases, Villanueva de la Torre, Matrix Biol, Lena Illert, Biol Chen, Van Eerdewegh, Human Ehlers-Danlos, Nat Med, Del Mastro, Van Leuven, Roles of Meltrin, Catalytic Dis, Bone Miner Res, Biochem Biophys Res Commun, University of Virginia New!
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cleaving aggrecan, human adamalysin, major sheddase, multidomain proteins with multiple functions, meltrin alpha, prodomain removal, meltrin beta, constitutive shedding, tumour necrosis factor alpha convertase, gene family encoding membrane proteins, native aggrecan, aggrecan catabolism, disintegrin loop, modular proteins capable, disintegrin domain, metalloproteinase with thrombospondin motifs, metalloprotease domain, ectodomain shedding, placental leucine aminopeptidase, gland expansion, aggrecanase activity, metalloprotease active site, active metalloprotease, bovine dermatosparaxis, constitutive cleavage Key Phrases - Capitalized Phrases (CAPs): (learn more)
Biol Chem, Cell Biol, Cell Sci, Proc Natl Acad Sci, Der Biol, Cancer Res, Genes Der, Exp Cell Res, New York, Arthritis Rheum, Family of Proteases, Villanueva de la Torre, Matrix Biol, Lena Illert, Biol Chen, Van Eerdewegh, Human Ehlers-Danlos, Nat Med, Del Mastro, Van Leuven, Roles of Meltrin, Catalytic Dis, Bone Miner Res, Biochem Biophys Res Commun, University of Virginia New!
Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 5
books:
- Glencoe Life Science by Lucy Daniel in Front Matter
- Cell Biology (Molecular and Cell Biochemistry Series) by C. A. Smith on page 168
- on page 16
- Physiology of Reproduction (2-Volume Set) by Ernst Knobil on page 259
- Proteases in the Brain (Proteases in Biology and Disease) by Uwe Lendeckel in Front Matter
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