"Advances in Down Syndrome Research” represents updated research in several areas of Down Syndrome (DS). A new promising animal model of DS is reported and this opens new opportunities to study pathomechanisms and pharmacological approaches as it is more than difficult to carry out studies in humans and the clinical features are highly variable. In terms of biology, cell cycle and stem cell studies and in terms of biochemistry, relevance of studies on a specific protein kinase, channels, transporters, superoxide dismutase, antioxidant system, chromosome assembly factor and other important biological structures are provided. And again, the gene dosage hypothesis is addressed and although the vast majority of chromosome 21 gene products is unchanged in fetal DS brain, a few specific chromosome 21 encoded structures including transcription factors are indeed overexpressed although findings in fetal DS are different from those in adult DS brain when Alzheimer-like neuropathology supervenes.
Advances in Down Syndrome Research
and over one million other books are available for Amazon Kindle.
Learn more
| ||||||||||||||||||||
Book Description
Product Details
Would you like to update product info or give feedback on images?
|
Customer Reviews
|
There are no customer reviews yet.
|
|||
|
Video reviews
|
Inside This Book
(learn more)
First Sentence:
FISH analysis was used to determine the retention rate of Chr 21 in cells from brain, heart, liver, spleen, bone-marrow, and in cultured tail-fibroblasts of adult chimeric mice. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
gene dosage hypothesis, neuronal target genes, beating cardiac myocytes, different cell cycle phases, chimeric fetuses, human amniotic fluid cells, silencer factor, freezing chain, segmental trisomy, abnormal folate metabolism, chromatin assembly factor, cytotrophoblastic cells, new mouse model, syndrome critical region, gene dosage effect, phospholipid transfer protein, anorectal malformations, folate carrier, human trisomy, syndrome brain, most common genetic cause, adenovirus receptor, diluted primary antibodies, brain samples, immunoreactive bands Key Phrases - Capitalized Phrases (CAPs): (learn more)
Biol Chem, Proc Natl Acad Sci, Neural Transm, University of Vienna, Biochem Biophys Res Commun, Brain Res, New York, Department of Pediatrics, Hum Mol Genet, Neurosci Lett, Amersham Pharmacia Biotech, Cell Biol, Hum Genet, Med Genet, Life Sci, King's College, Austria Summary, Introduction Down, Nat Genet, Santa Cruz Biotechnology, Ann Neurol, Dev Biol, Eleanor Roosevelt Institute, Exp Neurol, Red Bull Company New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Back Cover | Surprise Me!
FISH analysis was used to determine the retention rate of Chr 21 in cells from brain, heart, liver, spleen, bone-marrow, and in cultured tail-fibroblasts of adult chimeric mice. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
gene dosage hypothesis, neuronal target genes, beating cardiac myocytes, different cell cycle phases, chimeric fetuses, human amniotic fluid cells, silencer factor, freezing chain, segmental trisomy, abnormal folate metabolism, chromatin assembly factor, cytotrophoblastic cells, new mouse model, syndrome critical region, gene dosage effect, phospholipid transfer protein, anorectal malformations, folate carrier, human trisomy, syndrome brain, most common genetic cause, adenovirus receptor, diluted primary antibodies, brain samples, immunoreactive bands Key Phrases - Capitalized Phrases (CAPs): (learn more)
Biol Chem, Proc Natl Acad Sci, Neural Transm, University of Vienna, Biochem Biophys Res Commun, Brain Res, New York, Department of Pediatrics, Hum Mol Genet, Neurosci Lett, Amersham Pharmacia Biotech, Cell Biol, Hum Genet, Med Genet, Life Sci, King's College, Austria Summary, Introduction Down, Nat Genet, Santa Cruz Biotechnology, Ann Neurol, Dev Biol, Eleanor Roosevelt Institute, Exp Neurol, Red Bull Company New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Back Cover | Surprise Me!
Citations (learn more)
This book cites 9
books:
See all 9 books this book cites
- Advances in Research on Neurodegeneration: Volume 7 (Journal of Neural Transmission. Supplementa) by Yoshikuni Mizuno in Back Matter
- Protein Expression in Down Syndrome Brain (Springer Medicine) by G. Lubec in Back Matter
- The Red Cell: Seventh Ann Arbor Conference (Progress in clinical & biological research) by G.J. Brewer on page 81
- Down Syndrome by Sue Buckley on page 66
- New York by Tama Janowitz on page 18
See all 9 books this book cites
Books on Related Topics
(learn more)
|
Tag this product(What's this?)Think of a tag as a keyword or label you consider is strongly related to this product.
Tags will help all customers organize and find favorite items. |
Customer Discussions
|
This product's forum
Active discussions in related forums
Search Customer Discussions
|
Related forums
|
