Advancing Prion Science: Guidance for the National Prion Research Program [Paperback]

Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science (Author), Rick Erdtmann (Editor), Laura B. Sivitz (Editor)

Book Description

Publication Date: March 5, 2004

In "Advancing Prion Science", the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. "Advancing Prion Science" provides the first comprehensive reference on present knowledge about all aspects of TSEs - from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment.

Editorial Reviews

Book Description

In Advancing Prion Science, the Institute of Medicine’s Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense’s National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions’ normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs—from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment.

About the Author

Rick Erdtmann and Laura B. Sivitz, Editors, Committee on Transmissable Spongiform Encephalopathies: Assessment of Relevant Science

Product Details

• Paperback: 288 pages
• Publisher: National Academies Press; 1 edition (March 5, 2004)
• Language: English
• ISBN-10: 0309090601
• ISBN-13: 978-0309090605
• Product Dimensions: 9 x 6 x 0.7 inches
• Shipping Weight: 1.1 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #7,616,890 in Books (See Top 100 in Books)