What we now call deep venous thrombosis (DVT) has been elucidated by a diversity of investigative approaches during the past four centuries. The authors of this book survey the history of the field and ask: why has one of these perspectives the haematological/biochemical come to dominate research into the causation of DVT during the past 50 years and to exclude alternatives? In answering this question, they show that the current consensus model is conceptually flawed. Building on the work of William Harvey, John Hunter, Rudolf Virchow, Ludwig Aschoff and a number of pathologists in the mid-20<SUP>th</SUP> century, they offer a revised account of the aetiology of this condition. In the process they retrace and review the 160-year-old philosophical and methodological schism in biomedical research and, using DVT as an example, propose how this schism might be bridged to the benefit of both research and clinical practice.
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hypoxic endothelium, interrupted circulation, pathophysiological tradition, endothelial hypoxia, capillary phlebitis, venous blood movement, mural endothelium, aetiological sequence, platelet congregation, local hypoxaemia, hypoxia hypothesis, parietal valve, valve cusp leaflets, local blood velocity, experimental thrombi, ostial valves, valve thrombi, thrombi originate, colourless corpuscles, valve pockets, leukocyte debris, fibrin web, venous heart, local coagulation, valve cycle Key Phrases - Capitalized Phrases (CAPs): (learn more)
The Aetiology of Deep Venous Thrombosis, Springer Science, Molecular Changes, Business Media, The Role of Endothelial Hypoxia, Second World War, Die Cellularpathologie, The Valve Cusp Hypoxia Hypothesis, Agonal Thrombi, First World War, Cadaver Clots, History of Haematological Research, Historical Roots, The General Aetiological Sequence, The Coagulation Cascade Today, Phenotypic Changes, Study of Deep Venous Thrombosis, Berlin Physical Society, Bois Reymond, Klassiker de Medizin, Reflective Anamnesis, Clinical Implications Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Surprise Me!
hypoxic endothelium, interrupted circulation, pathophysiological tradition, endothelial hypoxia, capillary phlebitis, venous blood movement, mural endothelium, aetiological sequence, platelet congregation, local hypoxaemia, hypoxia hypothesis, parietal valve, valve cusp leaflets, local blood velocity, experimental thrombi, ostial valves, valve thrombi, thrombi originate, colourless corpuscles, valve pockets, leukocyte debris, fibrin web, venous heart, local coagulation, valve cycle Key Phrases - Capitalized Phrases (CAPs): (learn more)
The Aetiology of Deep Venous Thrombosis, Springer Science, Molecular Changes, Business Media, The Role of Endothelial Hypoxia, Second World War, Die Cellularpathologie, The Valve Cusp Hypoxia Hypothesis, Agonal Thrombi, First World War, Cadaver Clots, History of Haematological Research, Historical Roots, The General Aetiological Sequence, The Coagulation Cascade Today, Phenotypic Changes, Study of Deep Venous Thrombosis, Berlin Physical Society, Bois Reymond, Klassiker de Medizin, Reflective Anamnesis, Clinical Implications Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Surprise Me!
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