Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.
Aging of the Genome: The Dual Role of DNA in Life and Death
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Editorial Reviews
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'This is a work of real scholarship...'Nature, Vol 447, 17 May 2007.
About the Author
Jan Vijg is Professor at the Buck Institute for Age Research in Novato, California, USA.
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Science and technology extend life and improve the quality of life. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
aging phenome, premature aging symptoms, unrepaired somatic damage, epigenomic changes, increased genome instability, genome deterioration, reporter locus, premature aging phenotypes, large genome rearrangements, genome alterations, transcriptional noise, genome maintenance, segmental progeroid syndromes, longevity phenotype, longevity mutants, somatic genome, somatic maintenance, aging genes, increased genomic instability, extrinsic mortality, reporter mice, mutation accumulation, telomere attrition, mutation loads, replicative aging Key Phrases - Capitalized Phrases (CAPs): (learn more)
San Antonio, San Francisco, August Weismann, Denham Harman, Jeanne Calment, Martijn Dollé, Richard Miller, Alec Morley, Ann Arbor, Human Genome Project, Jan Gossen, John Maynard Smith, Paul Hasty, Peter Glazer, Rita Busuttil, Steve Austad New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Science and technology extend life and improve the quality of life. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
aging phenome, premature aging symptoms, unrepaired somatic damage, epigenomic changes, increased genome instability, genome deterioration, reporter locus, premature aging phenotypes, large genome rearrangements, genome alterations, transcriptional noise, genome maintenance, segmental progeroid syndromes, longevity phenotype, longevity mutants, somatic genome, somatic maintenance, aging genes, increased genomic instability, extrinsic mortality, reporter mice, mutation accumulation, telomere attrition, mutation loads, replicative aging Key Phrases - Capitalized Phrases (CAPs): (learn more)
San Antonio, San Francisco, August Weismann, Denham Harman, Jeanne Calment, Martijn Dollé, Richard Miller, Alec Morley, Ann Arbor, Human Genome Project, Jan Gossen, John Maynard Smith, Paul Hasty, Peter Glazer, Rita Busuttil, Steve Austad New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
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