This state-of-the-science reference provides valuable information on the pathophysiology and economic and social consequences of allergic skin reactions, as well as new treatments based on emerging concepts of skin disease pathobiology-addressing the epidemiology, mechanisms, occupational effects, environmental triggers, and quality-of-life concerns. Focuses on atopic dermatitis, urticaria, and allergic contact dermatitis, among other increasingly common skin disorders. Written by more than 35 leading researchers, Allergic Skin Disease · reviews basic principles of the causes of allergic skin responses · analyzes the role of key cell types, effector molecules, cytokines, mediators, chemokines, cell adhesion molecules, and immunogenetic mechanisms · showcases the dynamics of adhesion molecules and the pathophysiology of pruritus · examines clinical features of skin allergies, particularly regarding immune mechanisms that determine pathogenic course and outcome · investigates behaviors of keratinocytes, dendritic cells and macrophages, fibroblasts, lymphocytes, granulocytes, and endothelial cells · explores phototherapy, photochemotherapy, immunomodulatory therapy, and traditional antiinflammatory therapy for recalcitrant skin diseases · discusses anaphylaxis and other allergic reactions to insect bites · surveys demographism, vibratory angioedema, and other types of urticaria · identifies allergic and infectious triggers of skin disease · and more! Containing over 1800 bibliographic citations, Allergic Skin Disease is a must-read resource for dermatologists, allergists, immunologists, pharmaceutical and cosmetic chemists, internists, pediatricians, and graduate and medical school students in these disciplines.




