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The Amphipathic Helix
 
 
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The Amphipathic Helix [Hardcover]

Richard M. Epand (Author)

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Book Description

0849349265 978-0849349263 July 9, 1993 1
The Amphipathic Helix is a comprehensive volume discussing amphipathic helices in systems as diverse as serum lipoproteins, lung surfactant, cytotoxic peptides, ion channels, mitochondrial targeting, peptide hormones, G proteins, T-cell recognition, DNA binding proteins, and antifreeze proteins. The book also includes general introductory material that defines amphipathic helices, discusses methods to identify amphipathic helical segments from the amino acid sequence of a protein, illustrates how amphipathic helices can be used in the de novo design of peptide and protein structures, and describes how these helices stabilize protein structures. There is also a section on techniques to determine helix orientation in a membrane environment using polarized attenuated total reflection infrared spectroscopy or solid state NMR spectroscopy. Recent developments on all these topics have been discussed by leading experts in this reference for researchers and students in biochemistry, biophysics, and pharmacology.

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Inside This Book (learn more)
First Sentence:
An amphipathic a helix in its native state exhibits a periodicity in hydrophobicity of approximately 3.6 residues per turn. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
active presequences, amphipathic helical domains, synthetic presequences, amphipathic helix hypothesis, helical net representations, exchangeable apolipoproteins, deletion analogs, amphiphilic secondary structure, amphiphilic helical structures, amphipathic domains, high hydrophobic moment, individual apolipoproteins, amphipathic helical peptides, lipid affinity, helical net diagram, hysteresis activities, helical wheel diagram, hydrophobic positions, amphipathic segments, amphipathic helix motif, nonpolar face, melittin bound, amphipathic helices, amphipathic helical regions, antifreeze proteins
Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Protein Res, Methods Enzymol, None Cation, The Netherlands, Cell Biol, Lipid Res, Genes Dev, Plenum Press, Protein Chem, Trends Biochem, Academic Press, Activation of Purified, Boca Raton, Clarendon Press, Channel Ref, Cold Spring Harbor Symp, Ice Physics, John Wiley, Life Sci
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