This collection of invited papers from a Muscular Dystrophy Association-sponsored symposium provides coverage of clinical and basic research on amyotrophic lateral sclerosis (ALS) and other motor neuron diseases. Experts highlight new findings and theories on the molecular generics of these diseases, assess current concepts on immune-mediated motorneuron destruction and examine the pathogenesis of motor neuron disease induced by persistent viral infection. Several studies of amyotrophic lateral sclerosis/Parkinsonism-dementia complex in Guam offer new epidemiologic clues to the etiology of motor neuron diseases. Attention is also given to aluminium-induced motor neuron degeneration, post-radiation motor neuron syndromes and motor neuron disorders caused by other environmental agents. The book concludes with discussions on new approaches to designing and conducting clinical therapeutic trials in ALS.
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