Franka Potente plays Paula Henning, a young doctor-to-be who earns the right to study at a highly respected medical school in Heidelberg, the very school her proud, aging grandfather taught at years ago. She wants only to study and learn, but she ends up living with a fellow student from Munich named Gretchen (Anna Loos), who is quite a character in and of herself, and taking up with a strange fellow student named Caspar (Sebastian Blomberg) . The new students get an electrifying introduction to life at Heidelberg and soon begin their studies. When a young man whose life Paula had saved just days earlier turns up in the form of a cadaver on her lab table, she begins to grow uneasy. Convinced that the lad could not have died of his specific medical condition, she does a little research of her own and finds out that the guy was shot up with a substance that turns the blood into a rubbery substance. We the audience already know what happened to the poor guy; in fact, the opening scene of the movie takes us directly to a surgeon's table where a confused patient wakes up to find doctors basically turning his abdominal contents upside down. Such a scene might be a little disturbing to some, but the gore is, sadly, kept rather to a minimum throughout the entire movie.

A three-letter marking on her friend-turned-cadaver's body leads Paula into a realm of mystery, cruelty, and inherent danger. The Anti-Hippocratic Society, supposedly banned long ago, is apparently still operating under the noble auspices of Heidelberg's respected medical school; the members of this "secret lodge" don't let ethics or even common decency get in the way of their medical research, making a habit of dissecting human beings while these subjects are still alive. It's a pretty unpleasant business. To make matters worse, there is seemingly a rogue element of the Society at work, leading to several medical students themselves being killed not for dastardly research purposes but for emotional reasons. Yes, there is a madman somewhere out there, and Paula finds herself drawn farther and farther into his dangerous web. The genuine suspense that builds up over the last half of the film is energized further when Paula makes a shocking discovery that really hits her in the emotional gut.

The prominent bad guy sort of reveals himself a little early in the game, warning our heroine to stop nosing around, but his mysterious partner remains a mystery until the final moments. Bad Guy Number One, I think, goes a little overboard in his whole cool, calm, and collected closet psychotic behavior. I think he patterns much of his character's traits and behaviors on those of Herbert West of Reanimator fame, but these two characters are working at separate ends of the whole "life and death" spectrum and this guy is certainly no Jeffrey Combs. Still, it's fun to see a mad scientist-type villain take pride in his work.

Much of the gore involved in this subject matter presented on film is implied but not actually shown; while I personally would like to have been visually saturated in blood and guts, I think the lack of gore for gore's sake lends the movie a level of integrity that many a horror film cannot claim. The whole atmosphere of the film is palpable, the suspense builds up quite nicely, the ending comes with a potential little surprise, and Franka Potente is amazing. What's not to like? I should mention that this German film is dubbed in English, and while the dubbing isn't bad it necessarily denies us a complete sense of our characters' feelings at important moments. In the final analysis, this is quality dark entertainment that should please horror buffs as well as all Franka Potente fans in general.