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Angiotensin Receptors Medicinal Chemistry (Pharmacology and Toxicology)
 
 
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Angiotensin Receptors Medicinal Chemistry (Pharmacology and Toxicology) [Hardcover]

Robert R. Ruffolo (Editor)

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Book Description

0849385458 978-0849385452 November 30, 1994 1
This unique reference set provides a broad-based, in-depth presentation on angiotensin II receptors, from the genes that encode them to the responses they mediate in humans. The books emphasize known and potential therapeutic applications of the antagonists of angiotensin II receptors and the angiotensin-converting enzyme inhibitors. The molecular biology of angiotensin II receptors is reviewed, as are the biochemical effects mediated by angiotensin II receptors.
This is the first publication to analyze in detail the structure-activity relationships for both peptide and nonpeptide angiotensin II receptor agonists and antagonists. It also presents the pharmacological effects mediated by angiotensin II receptors both in the periphery and in the brain.

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Inside This Book (learn more)
First Sentence:
The renin-angiotensin system plays a central role in the regulation of blood pressure and fluid and electrolyte balance, and as a result, plays a major role in the pathophysiology of a number of disease states. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
rabbit aorta strip assay, percent activity relative, rat blood pressure assay, bearing conformational constraints, vivo antagonist activity, overlay hypothesis, receptor binding groups, agonist hypothesis, octapeptide antagonists, constrained amino acids, agonist conformation, angiotensin analogs, terminal carboxylate group, aromatic sidechains, multiple binding modes, constrained analogs, nonpeptide ligand, partial agonist activity, high receptor affinity, receptor bound conformation, pressor activity, antagonist analogs, constrained peptides, conformational models, rat mesentery
Key Phrases - Capitalized Phrases (CAPs): (learn more)
Agonist Antagonist, World Patent, New York, Med Chem, Peptide Svmp, Tetrazole Ref, American Chemical Society National Meeting, Ann Arbor, Peptide Symp, Ala Phe, Sar Ile, All-like All-liked, Van Meel, Ala Ile, Peptide Protein Res, Royal Society of Chemistry, San Francisco, Sar D-Phe, Activities of Position Eight Angiotensin, D-Arg D-Val D-Tyr D-Val D-His, German Patent, Life Sci, Macrocycle Formed, Marcel Dekker, Position Five Isoleucine
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