Animal Models in Toxicology (Drug and Chemical Toxicology) [Hardcover]

Shayne C. Gad (Editor)

Book Description

Publication Date: June 11, 1992 | ISBN-10: 0824784561 | ISBN-13: 978-0824784560 | Edition: 1

Providing step-by-step procedures specifically adapted to each of the major animal model species and describing the basic in vivo techniques used in toxicology and pharmacology, this single-source reference presents the information necessary to select appropriate in vivo models, design experiments, and interpret experimental results.;Furnishing physiological, preproductive, histopathological, clinical pathology, and anaesthesia data for the major laboratory species, Animal Models in Toxicology supplies a historical overview; discusses proper dosing techniques; examines common background diseases; details distinctive metabolic characteristics; demonstrates how to extrapolate results; and explicates animal welfare regulations.;With over 2600 literature citations and an appendix that lists the major commercial sources of laboratory animals, Animal Models in Toxicology is a comprehensive reference for toxicologists, pharmacologists, physiologists, and biochemists in pharmaceutical, clinical, biotechnology and contract laboratories; laboratory animal scientists and technicians; and upper-level undergraduate and graduate courses in animal pharmacology, experimental toxicology, comparative physiology, and experimental procedure.

Editorial Reviews

Review

. . .deals with the toxicology, pathology, and metabolism in all the standard animals with a chapter each of the following: rat, mouse, hamster, guinea pig, rabbit, ferret, dog, non human primates. There are also chapters on alternative species (earthworms, fish, minipigs); model selection and scaling; susceptibility factors; legal regulations; commercial sources of animals. All those who use laboratory animals will find this a useful book to read. Those carrying out drug tests will find it essential reading.
---International Journal of Biochemistry
. . .a valuable reference for toxicologists, pharmacologists, biochemists, physiologists, and other biomedical scientists who need authoritative information on the use of animal models in drug and chemical evaluation and risk assessment for teaching, research, testing, or regulatory purposes. This book should be in the personal libraries of the professionals mentioned above as well as in the libraries of all educational, industrial, commercial, regulatory, and research institutions serving those disciplines. . .an excellent choice as a supplemental reference text for a course in toxicological methods or research techniques.
---American Journal of Pharmaceutical Education
. . .the book achieves its aim admirably. Clear descriptions with excellent illustrations are given for procedures such as dosing and removal of body fluids for both rat and mouse, followed by an outline of the pathology that may affect the design and interpretation of experiments.
---Journal of Pharmaceutical Pharmacology
. . .highly recommended.
---Indian Journal of Toxicology

Product Details

• Hardcover: 928 pages
• Publisher: CRC; 1 edition (June 11, 1992)
• Language: English
• ISBN-10: 0824784561
• ISBN-13: 978-0824784560
• Product Dimensions: 10.2 x 7.5 x 1.8 inches
• Shipping Weight: 4 pounds
• Amazon Best Sellers Rank: #5,342,351 in Books (See Top 100 in Books)