Animal Models in Toxicology, Second Edition (Drug and Chemical Toxicology) [Hardcover]

Shayne C. Gad (Editor)

Book Description

ISBN-10: 0824754077 | ISBN-13: 978-0824754075 | Publication Date: October 30, 2006 | Edition: 2

Reflecting more than a decade’s worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of metabolism and relevance used in toxicology. Individual chapters covering the eight major species used in toxicology and experimental biology form the core of the book. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provide an excellent introductory “course” along with guidance to the literature for more detailed understanding.

The book goes on to make the case for a range of species not commonly used for safety assessment studies but which may provide useful alternative models for some specific endpoints. The chapter authors discuss special considerations regarding theevaluation and interpretation of the clinical pathology of the eight major model species as well as how to select a model species and how to extrapolate the results to humans. They detail potential pitfalls and situations that cause either human or model to be significantly more sensitive than the other or totally irrelevant to each other. The book concludes with an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized, and an appendix that provides a quick guide to commercial sources of laboratory animals.

Editorial Reviews

Review

“… a handbook detailing the characteristics and care of all the common species used in mammalian toxicology (mouse, rat, hamster, guinea pig, rabbit, ferret, dog, primates – rhesus and cynomolgus macaque, marmoset, chimps, squirrel monkeys, baboon and minipig). It also has a chapter on two key species sued in ecotoxicology (worms and fish). … If you want a book with lots of detailed general information on a test species and its care, this is your book. If you want to know how to extrapolate from animal to man, or between animal species, it’s a useful reference tool …”
— Tom Holmes, Covance Laboratories Ltd, UK, in bts – The British Toxicology Society, Issue 30, Summer 2007

Product Details

• Hardcover: 952 pages
• Publisher: CRC; 2 edition (October 30, 2006)
• Language: English
• ISBN-10: 0824754077
• ISBN-13: 978-0824754075
• Product Dimensions: 10.1 x 7.1 x 2.1 inches
• Shipping Weight: 3.7 pounds
• Average Customer Review: 3.0 out of 5 stars  See all reviews (1 customer review)
• Amazon Best Sellers Rank: #1,534,456 in Books (See Top 100 in Books)

Customer Reviews

Most Helpful Customer Reviews

3.0 out of 5 stars Informative but redundant, April 2, 2009

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Ratgurl "Ratgurl" (San Diego, CA) - See all my reviews

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This review is from: Animal Models in Toxicology, Second Edition (Drug and Chemical Toxicology) (Hardcover)

Though I have yet to read the book in its entirety, I have skimmed through several chapters & I find that much of the techniques appear to be written in redundancy. Perhaps I have high expectations, but perhaps techniques that are performed in the same manner between species could be consolidated and referenced. The information for actual toxicology in the various species is very useful.