This text covers significant aspects that are involved in the search, design and development of potential anti-AIDS agents, with emphasis on areas related to drug development. These include enzyme inhibitors (reverse transcriptase, protease, glucosidase), inhibitors of gene expression (oligonucleotides), viral binding inhibitors (anionic compounds and CD4 mimetics) and various plant-derived products. A focus of this book is the medicinal chemistry of these classes of compounds. In addition, other areas that are pertinent to drug development are also addressed. These include HIV regulatory proteins, the development of anti-HIV-1 assays and resistance to anti-HIV-1 agents.
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First Sentence:
Numerous compounds have been reported to inhibit the replication of human immunodeficiency virus (HIV) in vitro. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
virus ape, immunodeficiencv virus replication, naphthalenesulfonic acid derivatives, virus tvpe, immunodeficiencv virus type, nucleoside configuration, immunodeficiencyvirus type, drus type, antiviral activity spectrum, immunodeficiencv virus infection, human immunodeficiencv virus, cvtopathic effect, sulfonic acid polymers, pyridinone derivatives, chronically infected cells, dideoxynucleoside analogues, diminished susceptibility, tat antagonist, human immunodeficiency virus reverse transcriptase, constrained analog, sulfated polymers, syncytium formation, symmetric inhibitors, acyclic nucleoside phosphonates, sequential isolates Key Phrases - Capitalized Phrases (CAPs): (learn more)
Agents Chemother, Antiviral Res, Proc Natl, New York, International Conference, Antiviral Chem, American Chemical Society, National Cancer Institute, Tetrahedron Lett, Human Retrovir, Nucleic Acids Res, The Netherlands, Immune Defic, Van Daele, Abstracts of Papers, Antisense Res, Derivatives Structure-activity, Nusinoff Lehrman, Raven Press, Van Gelder, College of Pharmacy, Humana Press, Infect Dis, Proc Nad, San Francisco New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Numerous compounds have been reported to inhibit the replication of human immunodeficiency virus (HIV) in vitro. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
virus ape, immunodeficiencv virus replication, naphthalenesulfonic acid derivatives, virus tvpe, immunodeficiencv virus type, nucleoside configuration, immunodeficiencyvirus type, drus type, antiviral activity spectrum, immunodeficiencv virus infection, human immunodeficiencv virus, cvtopathic effect, sulfonic acid polymers, pyridinone derivatives, chronically infected cells, dideoxynucleoside analogues, diminished susceptibility, tat antagonist, human immunodeficiency virus reverse transcriptase, constrained analog, sulfated polymers, syncytium formation, symmetric inhibitors, acyclic nucleoside phosphonates, sequential isolates Key Phrases - Capitalized Phrases (CAPs): (learn more)
Agents Chemother, Antiviral Res, Proc Natl, New York, International Conference, Antiviral Chem, American Chemical Society, National Cancer Institute, Tetrahedron Lett, Human Retrovir, Nucleic Acids Res, The Netherlands, Immune Defic, Van Daele, Abstracts of Papers, Antisense Res, Derivatives Structure-activity, Nusinoff Lehrman, Raven Press, Van Gelder, College of Pharmacy, Humana Press, Infect Dis, Proc Nad, San Francisco New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 16
books:
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- Natural Products as Antiviral Agents by C.K. Chu on 7 pages
- Abstracts of Papers by American Chemical Society on page 112, and page 114
- Discovery of Novel Natural Products with Therapeutic Potential (Biotechnology) by Author Unknown on page 233
- Nucleosides and Nucleotides as Antitumor and Antiviral Agents by D.C. Baker on page 62
- Mechanisms of Action and Therapeutic Applications of Biologicals in Cancer and Immune Deficiency Disorders by Jerome E. Groopman on page 207
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