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Antibiotic Resistance: Understanding and Responding to an Emerging Crisis (FT Press Science) [Kindle Edition]

Karl S. Drlica , David S. Perlin
4.4 out of 5 stars  See all reviews (16 customer reviews)

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Book Description

Authored by two leading investigators, this book presents a thorough and authoritative overview of this multifaceted field of science. Pathogenic bacteria have been evolving and spreading resistance to diverse classes of antibiotics. As a result, we risk losing our ability to control and treat infectious diseases. Understanding antibiotic resistance, therefore, is becoming increasingly essential for a broad audience of healthcare professionals, biomedical and public health researchers, students, and policymakers. The authors answer questions such as: What is resistance? How does it emerge? How do common human activities contribute to resistance? What can we do about it? How can we strengthen our “first lines of defense” against resistance? Are there better ways to discover new antibiotics? What unique issues are associated with MRSA and viral influenza? In addition to defining and evaluating one of the most important emerging threats to public health, the authors explain what can be done to minimize risks to public health, and to preserve and extend the effectiveness of existing and new antibiotics.



Editorial Reviews

From the Back Cover

The emergence and spread of antibiotic resistance is a growing medical and public health emergency. Misuse and overuse of antibiotics is putting us at risk of losing our ability to cure infectious diseases. Karl Drlica and David S. Perlin give an authoritative and thorough explanation of all aspects of antibiotic resistance, from the basic science to the strategies that could minimize resistance problems and extend the life spans of existing antibiotic agents. Intended as the definitive book on a major biomedical issue, Antibiotic Resistance will be required reading for investigators and serious students in microbiology, infectious disease, pharmaceutics, and public health; physicians; and students in pharmacy, medicine, and veterinary medicine.

About the Author

Karl Drlica, Ph.D. is a Principal Investigator at the Public Health Research Institute and Professor of Microbiology & Molecular Genetics at the UMDNJ–New Jersey Medical School in Newark. His laboratory focuses on fluoroquinolone action and resistance with Mycobacteriun tuberculosis and other bacteria, including approaches for slowing the enrichment and amplification of resistant bacterial subpopulations.

 

David S. Perlin, Ph.D. is Executive Director of the Public Health Research Institute and UMDNJ Regional Biocontainment Laboratory, as well as Professor of Microbiology & Molecular Genetics at the New Jersey Medical School in Newark. He is also a Fellow of the New York Academy of Sciences. Dr. Perlin’s laboratory explores mechanisms of antifungal drug-resistance, rapid detection of drug resistant bloodstream pathogens in high-risk patients, and the application of small-animal models for the study of respiratory pathogens.


Product Details

  • File Size: 3830 KB
  • Print Length: 288 pages
  • Simultaneous Device Usage: Up to 5 simultaneous devices, per publisher limits
  • Publisher: FT Press; 1 edition (November 24, 2010)
  • Sold by: Amazon Digital Services, Inc.
  • Language: English
  • ASIN: B004DI7ISM
  • Text-to-Speech: Enabled
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  • Word Wise: Not Enabled
  • Lending: Not Enabled
  • Amazon Best Sellers Rank: #1,063,325 Paid in Kindle Store (See Top 100 Paid in Kindle Store)
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Customer Reviews

Most Helpful Customer Reviews
8 of 8 people found the following review helpful
4.0 out of 5 stars readable for a layman. too fundamental for experts March 28, 2011
Format:Hardcover|Vine Customer Review of Free Product (What's this?)
Having finished the book in one sitting, I flipped back to the preface in search of what its targeted audience is. It was "initially drafted to supplement studies of infectious disease" and the authors later "aim to make the principles of antibiotic use and effectiveness available to a large audience: farmers, hospital administrators.....and especially individual users."

The book's content and style of writing serves well for the above targeted audience. The book is suitable for use at a high school or college freshman year level as a supplement. Interesting historical facts and social ramifications interspersed throughout the book. The book is light on the academic or theoretical side of it, probably intentionally so. It touches on biological mechanisms just enough to make a layman understand what they want to tell next, nothing more. Nonetheless, this book is a laudable attempt to educate the public about the subject.
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7 of 8 people found the following review helpful
4.0 out of 5 stars Trying to Outwit Pathogens Isn't Easy February 9, 2011
Format:Hardcover|Vine Customer Review of Free Product (What's this?)
"...One of the Klebsiella pneumoniae isolates contained 2 integrons and was resistant to 8 antibiotics. Nucleotide sequence analysis of some of the integrons revealed a complex history involving insertion into a transposon and homologous recombination between transposons."

What's it all mean? I'm not sure, and unfortunately too much of the information in this timely, important book entered my brain like figures shrouded in smoke, visible yet not clearly identifiable, requiring the time and effort to blow away the smoke to come face to face with something unrecognizable anyway. Much of my denseness can be blamed on this English major's non-science background , and some may be attributed to the complexity of the subject matter itself.

The authors establish early that antibiotic resistance is an emerging crisis, one that needs to be addressed immediately, correctly, and ubiquitously to avoid future calamity and a regression in health care to the days before antibiotics. Their goal is widespread dissemination of their critical message and the hope that changes will be made by doctors, patients, governments, and the pharmaceutical companies. Drilica and Perlin state that for those with a solid biology background, "Antibiotic Resistance" will be a quick read. For the lay reader like myself, some chapters are tough to navigate though a glossary of terms is included to help one through the rough waters. I hope that later editions will include a more extensive glossary because some terms that baffled me were not listed.

This book is of interest to all but especially to those directly involved with antibiotics like nurses, those in paramedical fields, patients, and even farmers since many more tons of antibiotics are used on animals that on humans.
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3 of 3 people found the following review helpful
5.0 out of 5 stars Antibiotic Use: Cause and Effect April 1, 2011
Format:Hardcover|Vine Customer Review of Free Product (What's this?)
The authors outline and explain a problem that is not new but is starting to be brought into the public light. This book is written for people who use antibiotics and is written at an introductory yet clear level. The paramedics, farmers, hospital administrators and especially the public at large should read this book. If you do not have a background in basic biology the authors have included two appendix that give the basic background required to understand the rest of the text and I would recommend starting there.

The book is well presented on how the medical and agricultural use of antibiotics and their misuse has lead to pathogens mutating and becoming antibiotic resistance. And at present dosage and actually overuse of antibiotics will lead to a pathogen that will cause a pandemic. When is not discussed but when you read that rate at which the resistance strain mutate and spread it seems that this should be a subject of high priority. Yet pharmaceutical companies have been shutting down their antibiotic research division for it is not cost effective for them to continue.

The book is informative and not an alarmist manifesto. It covers the facts of use and history of antibiotics and present day measures. And proposes how we may be able to stop this path to a super resistant pathogen; a term not used by the authors. Most people know that the effectiveness of any type of drug diminishes with use and in low dosage the pathogens themselves become resistant. In order to rectify this situation will take a change of culture for all involved; farmers, medical professionals and moist important the general public. At present the authors show that all we are doing at present to slow down the spread and creation of antibiotic resistant pathogens is to increase dosage levels.
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4 of 5 people found the following review helpful
4.0 out of 5 stars First strike is still deadly February 2, 2011
Format:Hardcover|Vine Customer Review of Free Product (What's this?)
Antibiotic resistance is the ability of a microorganism to withstand the effects of an antibiotic.
Antibiotic resistance evolves naturally via natural selection through random mutation, but it could also be engineered by applying an evolutionary stress on a population. Antibiotic resistance is a consequence of evolution via natural selection.

Once such a gene is generated, bacteria can then transfer the genetic information in a horizontal fashion (between individuals) by plasmid exchange. "Antibiotic Resistance: Understanding And Responding To An Emerging Crisis" explains the concept of multiresistant organisms (aka; a "Superbug").

Bacteria which have a mutation allowing them to survive antibiotic intervention will live on to reproduce; passing on this resistance to their offspring in the next generation

Drlica & Perlin point out that the patterns of antibiotic usage greatly affect the number of resistant organisms which develop. Overuse of broad-spectrum antibiotics, such as second- and third-generation cephalosporins, greatly hastens the development of methicillin resistance.

Other factors contributing towards resistance include incorrect diagnosis, unnecessary prescriptions, improper use of antibiotics by patients, and the use of antibiotics as livestock food additives for growth promotion.

The book has the classic hallmarks of becoming a desktop reference for the clinician and those interested in new emerging bio-hazardous threats. I found the glossary very helpful and also the "light" and playful arrangement of facts an figures made the book enjoyable NOT another bland, boring "for scientists only". The layout reminded me of the "... For Dummies" and "The Complete Idiot's Guide To..." books. Which is a good thing. Comprehension of materials is the main point. No use having very dry, stuffy and hard to read or follow books ... which end up covered in dust and cobwebs for their unreadability.
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Most Recent Customer Reviews
4.0 out of 5 stars very educational, but a little dry
In Antibiotic Resistance: Understanding and Responding to an Emerging Crisis authors Karl Drlica and David Perlin take readers on a step by step tour of antibiotics, how and why... Read more
Published on January 22, 2012 by ephemeral
4.0 out of 5 stars For Scientists More than Laymen
I have a big interest in this topic because my son's first 10 years were constantly marked with raging ear infections. Read more
Published on December 11, 2011 by Brian D. Newby
4.0 out of 5 stars Strong Bugs
I read this book purely out of interest in the topic- I am semi- knowledgeable; not a professional, not your average Joe Schmoe. Read more
Published on November 26, 2011 by Book Dork
5.0 out of 5 stars An excellent review
This is definitely an excellent review of most of the issues surrounding antibiotic resistance and I consider it a necessary reference for anyone in the medical field. Read more
Published on October 2, 2011 by David Marks
4.0 out of 5 stars A sobering examination of the new dawn of germs that cannot be killed
It's hard to envision the world in the not to distant past, where even a minor injury or illness carried the real risk of being life threatening. Read more
Published on September 29, 2011 by hyytekk
5.0 out of 5 stars a midlevel book on antibiotic resistance, both the professional and...
Antibiotic Resistance is about an emerging crisis in medicine, namely, the increasing resistance that pathogens, such as bacteria, show to antibiotics. Read more
Published on May 18, 2011 by Patrick Regan
5.0 out of 5 stars Understanding those little things that make us sick
Here is the thing.....as a teacher in an Elementary school I see this whole sickness thing daily. I am not a science guy..... Read more
Published on May 9, 2011 by Wayne Crenwelge
5.0 out of 5 stars Very Informative
This book is an overview of antibiotics, how they work, and how their effectiveness is eroding through both natural processes and misuse. Read more
Published on March 24, 2011 by Erika Mitchell
4.0 out of 5 stars A comprehensive book with some organizational problems
This book was a bit out of the realm of what I usually review in that it is a textbook, which took me a bit by surprise for the Vine program. Read more
Published on March 14, 2011 by EJ
5.0 out of 5 stars Antibiotic Resistance: Understanding and Responding to an Emerging...
As one who has sat through many work related seminars concerning workplace safety and health related issues for those in the healthcare field, I often heard talk of a coming... Read more
Published on February 25, 2011 by D. Fowler
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