Antisense Technology in the Central Nervous System [Hardcover]

Ronald A. Leslie (Editor), Jackie Hunter (Editor), Harold A. Robertson (Editor)

Book Description

Publication Date: December 1999 | ISBN-10: 0198503164 | ISBN-13: 978-0198503163

Antisense technology has been used for several years to "knock down" the expression of specific genes in living tissues to study the functions of their protein products. Specifically designed antisense oligonucleotides (ODNs) are short lengths of man-made genetic material designed to interfere with the production of the protein encoded by the gene. This can shed light on the function of the protein; alternatively, if a disease process results from an excess of a certain protein, the method can in theory correct the problem. Faster than transgenic techniques, but more similarly problematic in practice, antisense has been seen as something of a "black art". There are many technical problems to understand and overcome. This is the first book to provide a critical review of the uses of this technology in the central nervous system. Antisense Technology in the Central Nervous System describes the promises and the pitfalls of this approach, and compares it to other approaches. The practical experience of leading researchers is combined with a thorough description of the theoretical foundation of the technique, making the book ideal for researchers and clinicians alike.

Editorial Reviews

Review

...This is the first book to provide a critical review of the uses of this technology in the central nervous system Aslib Book Guide --This text refers to an out of print or unavailable edition of this title.

About the Author

Ron A. Leslie, SmithKline Beecham Pharmaceuticals, Harlow. Jackie Hunter, SmithKline Beecham, Harlow. Harry Robertson, Professor and Head, Department of Pharmacology, Dalhousie University.

Product Details

• Hardcover: 270 pages
• Publisher: Oxford Univ Pr (December 1999)
• Language: English
• ISBN-10: 0198503164
• ISBN-13: 978-0198503163
• Product Dimensions: 9.4 x 6.3 x 0.8 inches
• Shipping Weight: 1.3 pounds (View shipping rates and policies)