Antisense Technology in the Central Nervous System [Paperback]

Ronald A. Leslie (Editor), A. Jackie Hunter (Editor), Harold A. Robertson (Editor)

Book Description

Publication Date: December 15, 1999 | ISBN-10: 0198505388 | ISBN-13: 978-0198505389 | Edition: 1

Antisense technology has been used for several years to "knock down" the expression of specific genes in living tissues to study the functions of their protein products. Specifically designed antisense oligonucleotides (ODNs) are short lengths of man-made genetic material designed to interfere with the production of the protein encoded by the gene. This can shed light on the function of the protein; alternatively, if a disease process results from an excess of certain protein, the method can in theory correct the problem. Faster thantransgenic techniques, but more problematic in practice, antisense has been seen as something of a "black art". There are many technical problems to understand and overcome.

Editorial Reviews

Review

...This is the first book to provide a critical review of the uses of this technology in the central nervous system Aslib Book Guide

About the Author

Ron A. Leslie, SmithKline Beecham Pharmaceuticals, Harlow. Jackie Hunter, SmithKline Beecham, Harlow. Harry Robertson, Professor and Head, Department of Pharmacology, Dalhousie University.

Product Details

• Paperback: 250 pages
• Publisher: Oxford University Press, USA; 1 edition (December 15, 1999)
• Language: English
• ISBN-10: 0198505388
• ISBN-13: 978-0198505389
• Product Dimensions: 9.1 x 5.9 x 0.6 inches
• Shipping Weight: 1 pounds
• Amazon Best Sellers Rank: #2,540,530 in Books (See Top 100 in Books)