Apoptosis: The Molecular Biology of Programmed Cell Death (Frontiers in Molecular Biology) [Paperback]

Michael Jacobson (Editor), Nicola McCarthy (Editor)

Book Description

Publication Date: June 20, 2002 | ISBN-10: 0199638497 | ISBN-13: 978-0199638499 | Edition: 1

Apoptosis is a regulated form of cell demise that can be induced or blocked by groups of specific stimuli. Occurring in all living tissues, it is thought critical to the maintenance of homeostasis and is implicated in lowering susceptibility to tumour growth. Conversely, over-sensitivity to apoptotic triggers can cause cells to be lost inappropriately from tissues, as appears to occur in neurodegenerative diseases. This book examines the molecular pathways regulating apoptosis, progressing from the nematode worm through Drosphila to the more complex pathways evident in mammalian cells. Differences in the cell death pathway within specific tissues are addressed, as are the different genes that may act to regulate progressive steps.

Editorial Reviews

Review

"[W]ell-written ... readable and thought provoking ... The editors each contribute excellent essays."--The Quarterly Review of Biology

About the Author

Michael Jacobson is at Millennium Pharmaceuticals Inc., Cambridge, MA, USA. Nicola McCarthy is at Division of Cardiovascular Medicine, Addenbrookes Hospital, Cambridge, UK.

Product Details

• Paperback: 346 pages
• Publisher: Oxford University Press, USA; 1 edition (June 20, 2002)
• Language: English
• ISBN-10: 0199638497
• ISBN-13: 978-0199638499
• Product Dimensions: 9.5 x 7.4 x 0.9 inches
• Shipping Weight: 1.8 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #2,803,855 in Books (See Top 100 in Books)