Approaches to High Throughput Toxicity Screening [Hardcover]

C. K. Atterwill (Editor), P. Goldfarb (Editor), W Purcell (Editor)

Book Description

ISBN-10: 0748407529 | ISBN-13: 978-0748407521 | Publication Date: December 16, 1999 | Edition: 1

The toxicology of safety testing of new pharmaceutical medicines using in vitro cell culture systems as animal alternatives in an important new science. The recent application of molecular biology (or toxicogenomics) to toxicity testing has enabled more accurate prediction of safety using in vitro systems and high throughput screening systems. These screening systems can be automated to provide fast, cost-effective and more ethical approaches to toxicity screening. Toxicogenomics is the study of organ and cellular responses to toxicity in terms of cellular stress gene induction. This family of genes (or stress gene `fingerprints') may in future allow accurate prediction of human hazard at low doses of compounds using human cell-bases systems. The recent development of gene expression microarrays (GEMs) in-situ based assays for stress gene induction using gene-probes (e.g. scintillation proximity assays and reporter gene technology) and organotypic culture systems (e.g. liver and brain spenoids) has and will enable automation and miniturisation of toxicogenomic-based high throughput screens in toxicology and drug metabolism. This book takes an integrated approach to in vitro toxicology and ADME screening using these new technologies and discusses how they might be applied to the pre-clinical safety assessment and `lead optimisation' of new pharmaceutical products in drug discovery. Edited and written by leading authorities in the field, this practical and comprehensive volume will be valuable reading for postgraduate and professional toxicologists and pre-clinical scientists in academia, contract testing organisations and the chemical and pharmaceutical industries.

Product Details

• Hardcover: 200 pages
• Publisher: CRC; 1 edition (December 16, 1999)
• Language: English
• ISBN-10: 0748407529
• ISBN-13: 978-0748407521
• Product Dimensions: 10 x 7 x 0.7 inches
• Shipping Weight: 1.3 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #5,188,014 in Books (See Top 100 in Books)