The Art of Drug Synthesis [Hardcover]

Douglas S. Johnson (Editor), Jie Jack Li (Editor)

Book Description

ISBN-10: 0471752150 | ISBN-13: 978-0471752158 | Publication Date: July 9, 2007 | Edition: 1

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis.

• Edited by prominent scientists working in drug discovery for Pfizer
• Meets the needs of a growing community of researchers in pharmaceutical R&D
• Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students
• An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

Editorial Reviews

Review

“This is a most topical and useful short primer on estab1ished drugs and their synthesis.” (American Journal of Therapeutics, June 2009)

"The book is very felicitous and closes a gap in the literature by covering the subject of drug development in this particular way." (Angewandte Chemie, June 23, 2008)

"This book is a very entertaining read." (ChemMedChem, 2008, 3)

"The editors and contriubting authros have certainly provided a most useful book for the medicinal and organic chemistry community." (Journal of Medicinal Chemistry, March 2008)

"Where I see the book being very useful is as a starting point for student seminars or discussion groups... Also, it is highly illuminating just to dip into for a browse and to marvel at some of the excellent chemistry that goes on in the pharmaceutical industry." (Chemistry World, January 2008)

From the Back Cover

DISCOVER  THE INS ANDOUTS OF DRUG SYNTHESIS, FROM IDENTIFYING A LEAD MOLECULE TO COMMERCIAL PRODUCTION.

Learn how chemistry, biology, pharmacokinetics, and a host of other disciplines all play a role in the successful discovery of new drugs and therapeutics. This text features contributions from seventeen leading medicinal and process chemists who show you how it is done. Some of the contributors were instrumental in the discovery of the drugs they review, offering you a unique and invaluable perspective on the complete drug discovery process.

The first two chapters of this text introduce the stringent requirements for a potential therapeutic molecule, approaches in finding molecular structures that 'hit" a biological target, and the many steps needed to go from initial small-scale laboratory synthesis to commercial and the many steps needed to go from initial small-scale laboratory synthesis to commercial production. The remaining fifteen chapters are divided into three major therapeutic areas:

• Cancer and infectious Diseases
• Cardiovascular and Metabolic Diseases
• Central Nervous System Diseases

These three section collectively cover twenty-one categories of drugs and more than sixty individual drugs, highlighting both medicinal and process synthetic routes. The authors present detailed accounts of the synthesis of such high-profile drugs as Actos®, Levaquin®, Avelox®, Diflucan®, Tamiflu®, Zetia®, Lyrica®, and Strattera®. You gain new insight into how a first generational agent is refined and improved by the application of medicinal chemistry for the discovery of second and third generation medicines.

This text is an excellent companion to the bestselling Contemporary Drug Synthesis, covering all new drugs. In addition to serving as a reference for medicinal chemists and pharmacologists, this book is highly recommended as a graduate-level text for medicinal pharmacologists, this book is highly recommended as a graduate-level text for medicinal and pharmaceutical chemistry courses. With its many examples and insights into successful and pharmaceutical chemistry courses. With its many examples and insights into successful syntheses, it enables students to make the bridge from theory to practice.

See all Editorial Reviews

Product Details

• Hardcover: 296 pages
• Publisher: Wiley-Interscience; 1 edition (July 9, 2007)
• Language: English
• ISBN-10: 0471752150
• ISBN-13: 978-0471752158
• Product Dimensions: 7.2 x 0.9 x 10.2 inches
• Shipping Weight: 1.4 pounds (View shipping rates and policies)
• Average Customer Review: 3.5 out of 5 stars  See all reviews (2 customer reviews)
• Amazon Best Sellers Rank: #530,287 in Books (See Top 100 in Books)

Customer Reviews

Most Helpful Customer Reviews

1 of 2 people found the following review helpful:

3.0 out of 5 stars Not quite what I hoped for, February 24, 2010

By 

Jeff Evarts "You do NOT need permission to ea... (Thousand Oaks, California) - See all my reviews

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This review is from: The Art of Drug Synthesis (Hardcover)

This is a collection of essays, some both relevant and well written, some not so much.

I was personally hoping for something a little more consistent, and a lot more comprehensive.

It is what it is, so I rated it 3 stars.

1 of 3 people found the following review helpful:

4.0 out of 5 stars Drug synthesis explained plain and simple, February 18, 2010

By 

Eric Ballard "True knowledge exists in knowin... (Groton, CT United States) - See all my reviews
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This review is from: The Art of Drug Synthesis (Hardcover)

This is an interesting book and it is short, sweet and to the point. The work basically covers drugs by use, how they were discovered, how they work (briefly normally) and then how they were synthesized. The book is mostly concerned with the synthesis of the drugs in question and then how to make the synthesis more applicable to an industrial setting normally with several generational approaches to the synthesis. It's an instructive book and a great reference when you need to know what drug does "what", its mechanism of action and how exactly the drug was synthesized.