Asymmetric Organocatalysis: From Biomimetic Concepts to Applications in Asymmetric Synthesis [Hardcover]

Albrecht Berkessel (Author), Harald Gr?ger (Author), David MacMillan (Foreword)

Book Description

Publication Date: March 28, 2005 | ISBN-10: 3527305173 | ISBN-13: 978-3527305179 | Edition: 1

Asymmetric catalysis represents still one of the major challenges in modern organic chemistry. Besides the well-established asymmetric metal-complex-catalysed syntheses and biocatalysis, the use of "pure" organic catalysts turned out to be an additional efficient tool for the synthesis of chiral building blocks. In this handbook, the experienced authors from academia and industry provide the first overview of the important use of such metal-free organic catalysts in organic chemistry. With its comprehensive description of numerous reaction types, e.g., nucleophilic substitution and addition reactions as well as cycloadditions and redox reactions, this book targets organic chemists working in industry and academia, and deserves a place in every laboratory.

Editorial Reviews

Review

"This monograph will be a valuable addition into personal collections of synthetic chemists and research libraries of academia and industry." (E-STREAMS, June 2006)

"…well-written with clear, focused schemes…of great value to those involved in synthetic methodology, catalysis, and total synthesis." (Journal of the American Chemical Society, October 19, 2005)

"This fascinating monograph captures the diversity and power of an area of research whose roots extend deep within the organic chemistry literature, yet which has only recently achieved critical mass through the collective contributions of many present-day pioneers.... is an essential addition to both academic and industrial research libraries, as well as to the personal collection of any scientist with an interest in catalysis or synthetic chemistry." (Angewandte Chemie I.E.)

"This book can be recommended for all scientists working in the area of asymmetric catalysis, whether in industrial research and development or at the universities." (Synthesis, February 2006)

 

From the Back Cover

Asymmetric catalysis is of ever-increasing importance in organic synthesis, both in the academic and the industrial environment. Between the extremes of metal-based and biocatalytic methods, the use of low-molecular weight and purely organic catalysts has become a third and highly efficient tool for enantioselective transformations. In this book, two experienced authors from academia and industry provide the first comprehensive overview of both the development and the current state of asymmetric organocatalysis. After a historical introduction, all synthetically relevant reaction types, such as nucleophilic substitution, addition to C=X bonds, cycloadditions and redox reactions are thoroughly discussed in a total of 11 chapters, followed by a consideration of large scale applications of organocatalysis. Additionally, the most frequently used organocatalysts and their properties are summarized in an appendix, aiding the research chemist in selecting an appropriate catalyst for a given transformation. Overall, this book targets organic chemists active both in industry and academia, and it deserves a place in every laboratory.

From the Contents:

• Introduction: Organocatalysis - From Biomimetic Concepts to Powerful Methods for Asymmetric Synthesis
• Nucleophilic Substitution at Aliphatic Carbon, e.g. Amino Acid Synthesis by Alkylation
• Nucleophilic Addition to C=C, C=N, C=O, N=N and N=O Double Bonds
• Synthesis of Epoxides and Aziridines
• Cycloaddition Reactions
• Protonation of Enolates
• Oxidation/Reduction
• Kinetic Resolution of Racemic Alcohols and Amines
• Desymmetrization of meso- and prochiral Compounds
• Large-scale Applications
• Appendix: Tabular Survey of Frequently used Organocatalysts

See all Editorial Reviews

Product Details

• Hardcover: 454 pages
• Publisher: Wiley-VCH; 1 edition (March 28, 2005)
• Language: English
• ISBN-10: 3527305173
• ISBN-13: 978-3527305179
• Product Dimensions: 7 x 1.1 x 9.7 inches
• Shipping Weight: 2.2 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #3,248,098 in Books (See Top 100 in Books)
  • #72 in Books > Professional & Technical > Professional Science > Chemistry > Organic > Synthesis

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