There is a large, but widely dispersed body of literature documenting the potential of drugs and chemicals to induce autoimmune phenomena, especially in man. The available data combined with the fact that the compounds are chemically well-defined provides immunologists and toxicologists with a solid base for studying the etiopathology of autoimmune disorders. Attemps to develop animal models for the study of chemical-induced autoimmune disorders have been frustrating, and only recently, as this book shows, have several interesting and reproducible models become available. This volume presents the field of drug- and chemical-induced autoimmunity in an extremely coherent manner by reviewing the subject from a basic immunological, clinical, chemical and toxicological perspective. Only a selected number of compounds with autoimmunity-inducing potential has been reviewed and the conditions reviewed under which these compounds induce autoimmune disorders.
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