Progress in Clinical and Biological Research, Volume 392 Bacterial Endotoxins Lipopolysaccharides From Genes to Therapy Proceedings of the Third Conference of the International Endotoxin Society, Held in Helsinki, Finland, August 15–18, 1994 Jack Levin, Carl R. Alving, Robert S. Munford, and Heinz Redl, Editors In the past two decades, the scope of research in the field of bacterial endotoxins has expanded dramatically. Bacterial Endotoxins: Lipopolysaccharides From Genes to Therapy contains the most recent basic and clinical work of researchers studying lipopolysaccharides (LPS), including everything from recent findings on the molecular genetics and biosynthesis of LPS, to various aspects of endotoxin tolerance. Assembling information from the work of renowned international researchers, the book is divided into ten well-organized sections, each of which includes papers representing the state of the art in LPS investigations. Specific topics covered in the text include:
- the structure and biosynthesis of Rhizobium leguminosarum lipid A
- conformation and fluidity of endotoxins as determinants of biological activity
- modalities of endotoxin binding to CD14
- rational computer-aided design of ligands that bind endotoxin
- formation of a TNF synthesis inhibitor in endotoxin tolerance
- monophosphoryl lipid A as a prophylactic for sepsis and septic shock
