This volume provides a brief but important summary of the essential tests that need to be performed on all new compounds--whether they are new drugs, pesticides or food additives--before they can be registered for use in the United Kingdom. These basic tests for mutagenicity, originally drawn up by the United Kingdom Environmental Mutagen Society in 1983 have now been fully revised under the auspices of expert working groups from academia and industry and in collaboration with the UK Department of Health. This volume therefore provides the latest official guidelines and recommendations for all scientists involved in the testing and registration of new compounds not only in the UK, but in wider international context. The four main test procedures for measuring mutagenicity described in this volume are bacterial mutation assays, metaphase chromosome aberration assays in vitro, gene mutation assays in cultured mammalian cells, and in vivo cytogenetics assays. Each of these tests is fully explained and described in practical and procedural detail, with additional information on the presentation and data processing of results.
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This gives a brief but important summary of the essential tests that must be performed on all new compounds, whether they be new drugs, pesticides or food additives, before they can be registered for use in the UK. It gives the latest official guidelines and recommendations for scientists involved in testing and registration of new compounds.
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Inside This Book
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First Sentence:
In March 1982 the United Kingdom Environmental Mutagen Society (UKEMS) appointed a Sub-committee to report on the minimal professional criteria that should be applied to mutagenicity testing in order to meet the requirements of the UK authorities. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
basic test battery, additional sampling time, bacterial mutation tests, reference mutagens, fluctuation assays, bacterial mutation assays, typhimurium tester strains, metabolising systems, metaphase analysis, thymidine kinase locus, fluctuation test, mutant frequency, micronucleus test, mutagenicity testing, gene mutation assays, metabolic activation system, background lawn, mouse lymphoma cells, cytogenetic assays, mitotic delay, human lymphoblastoid cells, micronucleus assay, polychromatic erythrocytes, hamster cells, test agent Key Phrases - Capitalized Phrases (CAPs): (learn more)
Mutation Research, New York, Environmental Mutagenesis, Environmental Protection Agency, United Kingdom Environmental Mutagen Society, Cambridge University Press, Cold Spring Harbor Laboratory, Statistical Evaluation of Mutagenicity Test Data, Advisory Committee, Ames Salmonella, Supplementary Tests, Cancer Research, Environmental Mutagenests, Plenum Press, Academic Press, Critical Appraisal, Dangerous Pathogens, Federal Register, Pharmaceutical Affairs Bureau, Practical Approach New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
In March 1982 the United Kingdom Environmental Mutagen Society (UKEMS) appointed a Sub-committee to report on the minimal professional criteria that should be applied to mutagenicity testing in order to meet the requirements of the UK authorities. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
basic test battery, additional sampling time, bacterial mutation tests, reference mutagens, fluctuation assays, bacterial mutation assays, typhimurium tester strains, metabolising systems, metaphase analysis, thymidine kinase locus, fluctuation test, mutant frequency, micronucleus test, mutagenicity testing, gene mutation assays, metabolic activation system, background lawn, mouse lymphoma cells, cytogenetic assays, mitotic delay, human lymphoblastoid cells, micronucleus assay, polychromatic erythrocytes, hamster cells, test agent Key Phrases - Capitalized Phrases (CAPs): (learn more)
Mutation Research, New York, Environmental Mutagenesis, Environmental Protection Agency, United Kingdom Environmental Mutagen Society, Cambridge University Press, Cold Spring Harbor Laboratory, Statistical Evaluation of Mutagenicity Test Data, Advisory Committee, Ames Salmonella, Supplementary Tests, Cancer Research, Environmental Mutagenests, Plenum Press, Academic Press, Critical Appraisal, Dangerous Pathogens, Federal Register, Pharmaceutical Affairs Bureau, Practical Approach New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 11
books:
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- Statistical Evaluation of Mutagenicity Test Data by David J. Kirkland on 8 pages
- ENVIRONMENTAL MUTAGENESIS (Human Molecular Genetics) by D.h. Phillips on page 52, page 58, and page 60
- Mutagenicity Testing: A Practical Approach by S. Venitt on page 61, and page 84
- Chemical Mutagens: Principles and Methods for Their Detection by Frederick J. De Serr on page 139, and page 140
- Mammalian Cell Mutagenesis (Banbury Report) by Martha M. Moore on page 111, and page 112
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