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  • Bayer Advantage II, Large Dogs, 21 to 55-Pound, 4-Month
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Bayer Advantage II Topical Flea Treatment Dogs

by Bayer
1,442 customer reviews

List Price: $54.54
Price: $40.98 & FREE Shipping
You Save: $13.56 (25%)
Only 4 left in stock.
Ships from and sold by Luty's Pet Shoppe.
21 to 55-Pound
4-Month
  • Kills adult fleas, eggs and larvae
  • Remains effective even after swimming or shampooing
  • One treatment prevents further flea infestation for at least four weeks
  • Packaging may vary
8 new from $38.48

$40.98 & FREE Shipping Only 4 left in stock. Ships from and sold by Luty's Pet Shoppe.

Frequently Bought Together

Bayer Advantage II, Large Dogs, 21 to 55-Pound, 4-Month + Bayer Advantage II, Large Cat, Over 9-Pound, 6-Month
Price for both: $93.97

These items are shipped from and sold by different sellers.

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Product Description

Size:21 to 55-Pound  |  Style:4-Month

Biting fleas are more than just a nuisance for your dog. Left unchecked, they can cause serious disorders such as flea allergy dermatitis, secondary skin infections, tapeworms, and even anemia. This topical flea treatment lets you stop fleas before they become a problem. Used just once a month, it begins working in minutes, killing 98 to 100 percent of the fleas on dogs within 12 hours and 99 percent of flea larvae and eggs within 20 minutes. The dead fleas can't lay eggs, and the dead larvae and eggs can't hatch, breaking the flea's life cycle and halting the infestation in its tracks. Any new fleas your dog then encounters are killed within two hours, preventing re-infestation for as long as four weeks. In fact, Advantage II is so effective at breaking the flea's life cycle there's no need to treat your dog's environment. Applied before the start of flea season, it helps keep your dog from becoming infested in the first place. Used year-round, it prevents fleas from over-wintering in your home to feast on your dog next season. Gentle enough for puppies as young as seven weeks, Advantage II is water-resistant and continues to work while your dog swims or is bathed. The package includes four pre-measured doses for dogs 21-55 pounds in easy-to-use applicator tubes. For safety, keep out of the reach of children, and read all warnings and instructions carefully.


Product Details

Size: 21 to 55-Pound | Style: 4-Month
  • Product Dimensions: 6.5 x 1 x 4.2 inches ; 1.6 ounces
  • Shipping Weight: 1.6 ounces (View shipping rates and policies)
  • Domestic Shipping: Item can be shipped within U.S.
  • International Shipping: This item is not eligible for international shipping. Learn More
  • ASIN: B004QRFJA4
  • Item model number: 4461758
  • Average Customer Review: 4.2 out of 5 stars  See all reviews (1,442 customer reviews)
  • Amazon Best Sellers Rank: #3,257 in Pet Supplies (See Top 100 in Pet Supplies)
  • Product Warranty: For warranty information about this product, please click here

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Customer Questions & Answers

Customer Reviews

Most Helpful Customer Reviews

887 of 911 people found the following review helpful By Nunja Business on July 26, 2012
Style Name: 4-MonthSize: 55-Pound Verified Purchase
The drug in Advantage II for Dogs and Advantage II for Cats is exactly the same drugs (Imidacloprid and Pyriproxyfen) at the exact same concentrations.
If you buy this "Large Dog" package, you get four 4ml tubes. If you then empty those into a vial or vials, you can use a syringe (without needle) to apply the right dosage to your dogs AND cats. In fact, if your cats are under 10 pounds, you can get 10 cat doses out of each of these vials. That's a real bargain!

I am a former Vet Tech and can assure you I have been doing this for years (with Advantage first, and now Advantage II) with ZERO problems.

Use the following chart and you will be fine.
Cats up to 9 pounds - 0.4ml
Cats 10+ pounds - 0.8ml
Dogs 11-20 pounds - 1.0ml
Dogs 21-55 pounds - 2.5ml
Dogs 55+ pounds - 4.0ml
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120 of 124 people found the following review helpful By Frank R. Nichols on September 28, 2011
Style Name: 4-MonthSize: 21 to 55-Pound Verified Purchase
I've been happily using these types of flea medications for 10 years. BUT, I'd given up over the last two years on Advantage and Frontline. They both seemed to have NO EFFECT. Maybe the fleas in my area had become immune? I tried the others from the local big box store, they didn't work either.

I thought I'd try this "advantage II", maybe Bayer had changed the forumulation?

To my surprise - it worked great! I have two 60 lb dogs (shepherd and golden retriever) who were miserable this summer, as was I, because neither my Shepherd nor I enjoyed weekly baths to try to control the fleas.

This stuff is magic.

No more fleas on my pets or in my carpets.
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18 of 19 people found the following review helpful By Robert W. Lawrence on January 15, 2012
Style Name: 6-MonthSize: 21 to 55-Pound Verified Purchase
Frontline was failing miserably for us. I switched to Advantage II and the fleas are quickly and finally gone. Only draw back is that it doesn't kill ticks.
No adverse reactions on our Cocker at all!
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71 of 86 people found the following review helpful By Gail Dehghani-sanich on June 10, 2011
Style Name: 4-MonthSize: 55-Pound Verified Purchase
We have over 10 cats at any time and this is a godsend. We treat the animals by weight(you can find this info on-line) using the large dog size. It is exactly the same ingredients as the cat one just different dosage. Advantage II is even better! It kills fleas quicker and kills the eggs too. We used to use Frontline Plus but was seeing adult fleas in 1-2 weeks. I am glad we changed to this product. Price is great too.
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21 of 23 people found the following review helpful By JasmineG on May 24, 2012
Style Name: 6-MonthSize: 21 to 55-Pound Verified Purchase
Fleas were gone within 24 hours. I noticed he had stoped biting and whining also within 24 hours. It actually lasted 2 weeks longer than they said it should on the package which is nice in this economy, if it last longer you use less and pay less. I will definitely buy this product again when I run out.
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32 of 38 people found the following review helpful By Ellenlee36 on July 6, 2011
Style Name: 6-MonthSize: 55-Pound Verified Purchase
I just wanted to say I run a cat rescue and with the 6 month supply i can cover over 28 cats and 3 small dogs, i wish you sold the 12 month supply but ill take what i can get and i always remember the puppy on the commercial
:there aint no bugs on me there aint no bugs on there may be bugs on some of you mugs but there aint no bugs on me!!!!" had to add that becasue im sure you have all seen it lol have a safe and happy summer!! Ellen Hobbs
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18 of 20 people found the following review helpful By Casey Kyle Wilson on December 8, 2011
Style Name: 4-MonthSize: 11 to 20-Pound
I have used Frontline for years and it always took and week to kick in and only lasted for about 2 weeks and my dog started scratching like crazy again. So I switched to this and it worked in just one day and lasts for a full month!!! My dog has never been happier!!
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19 of 22 people found the following review helpful By DJM on June 9, 2010
Style Name: 4-MonthSize: 55-Pound Verified Purchase
I love this product and have been using it on my cats for years. I buy the large dog pack because its cheaper to buy this and put the medicine in a dropper using the proper dosage for my cats. It lasts forever and it much more economical to do it this way.
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