This unique book presents a systematic review of the methods for the determination of binding constants of complex formation in solution. Collects material that has been scattered throughout the literature of several separate fields. Offered here are methods from the areas of acid-base chemistry, metal-ion coordination compounds, hydrogen-bonding, charge-transfer complexation, hydrophobic interaction, and protein-binding. Discusses the relevant thermodynamics, modelling, statistics and regression analysis, and interpretation of data. Includes fresh discussions of random association (contact complexes), selection of standard states, and comparison of results. Treats all of the experimental methods useful for measuring these equilibrium constants, including those based on spectrophotometry, nuclear magnetic resonance, reaction kinetics, potentiometry, solubility, liquid-liquid partitioning, dialysis, chromatography, flourimetry, and many others.
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This unique book presents a systematic review of the methods for the determination of binding constants of complex formation in solution. Collects material that has been scattered throughout the literature of several separate fields. Offered here are methods from the areas of acid-base chemistry, metal-ion coordination compounds, hydrogen-bonding, charge-transfer complexation, hydrophobic interaction, and protein-binding. Discusses the relevant thermodynamics, modelling, statistics and regression analysis, and interpretation of data. Includes fresh discussions of random association (contact complexes), selection of standard states, and comparison of results. Treats all of the experimental methods useful for measuring these equilibrium constants, including those based on spectrophotometry, nuclear magnetic resonance, reaction kinetics, potentiometry, solubility, liquid-liquid partitioning, dialysis, chromatography, flourimetry, and many others.
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3 of 3 people found the following review helpful:
5.0 out of 5 stars
Couldn't have done without it,
By Not me (Pasadena, CA) - See all my reviews
This review is from: Binding Constants: The Measurement of Molecular Complex Stability (Hardcover)
This was the bible for measuring affinity constants during my Ph.D. It was the first and often only reference for many techniques we used. It is a must have, even at this price.
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Inside This Book
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First Sentence:
This book is about molecular complexes, species formed by the association of two or more interactant molecules. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
linear plotting forms, stepwise binding constants, total substrate concentration, complexing system, free substrate concentration, different ligand concentrations, microscopic binding constants, free ligand concentration, apparent partition coefficient, mass balance expressions, nonideality effects, slow exchange limit, solubility method, probe phase, total ligand concentration, solubility diagram, stoichiometric model, binding isotherm, mole fraction scale, titrant volume, high ligand concentration, fast exchange limit, concentration scale, substrate species, molar scale Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, University of Wisconsin-Madison, Combining Eqs, Acta Chem, Ellis Horwood, Dover Publications, Faraday Trans, San Francisco, Biophysical Chemistry, Electrolyte Solutions, Faraday Soc, Perkin Trans, Van Nostrand Reinhold, Acta Pharm, Chemistry of Complex Equilibria, Examples of Models, Molecular Associations, Solution Chem, Statistical Adjustment of Data, Statistical Thermodynamics, Applied Regression Analysis, Cambridge University Press, Comparison of Eqs, Donor-Acceptor Bond, Halsted Press New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
This book is about molecular complexes, species formed by the association of two or more interactant molecules. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
linear plotting forms, stepwise binding constants, total substrate concentration, complexing system, free substrate concentration, different ligand concentrations, microscopic binding constants, free ligand concentration, apparent partition coefficient, mass balance expressions, nonideality effects, slow exchange limit, solubility method, probe phase, total ligand concentration, solubility diagram, stoichiometric model, binding isotherm, mole fraction scale, titrant volume, high ligand concentration, fast exchange limit, concentration scale, substrate species, molar scale Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, University of Wisconsin-Madison, Combining Eqs, Acta Chem, Ellis Horwood, Dover Publications, Faraday Trans, San Francisco, Biophysical Chemistry, Electrolyte Solutions, Faraday Soc, Perkin Trans, Van Nostrand Reinhold, Acta Pharm, Chemistry of Complex Equilibria, Examples of Models, Molecular Associations, Solution Chem, Statistical Adjustment of Data, Statistical Thermodynamics, Applied Regression Analysis, Cambridge University Press, Comparison of Eqs, Donor-Acceptor Bond, Halsted Press New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 30
books:
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11
books
cite this book:
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- Solution Equilibria by F. R. Hartley on 4 pages
- The Hydrophobic Effect: Formation of Micelles and Biological Membranes by Charles Tanford on page 19, page 98, and page 99
- Statistical Adjustment of Data (Dover Books on Mathematics) by W. Edwards Deming on page 136, page 137, and Back Matter
- Hydrogen Bond (Books in Chemistry S.) by A.L. McClellan George C. Pimentel on page 19, page 98, and page 187
- Organic Chemistry by Wiley on page 185, page 280, and page 318
See all 30 books this book cites
- Chemical Kinetics: The Study of Reaction Rates in Solution by Kenneth A. Connors on 4 pages
- Chemical Kinetics: The Study of Reaction Rates in Solution by Kenneth A. Connors on 4 pages
- The Biorganic Chemistry of Enzymatic Catalysis: An Homage to Myron L. Bender by Valerian T. D'Souza on page 25
- Electronic Noses and Sensors for the Detection of Explosives (NATO Science Series II: Mathematics, Physics and Chemistry) by J. Gardner on page 51
- In Vitro Neurochemical Techniques (Neuromethods) by Alan A. Boulton on page 35
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