Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches, and Development (Drugs and the Pharmaceutical Sciences) [Hardcover]

Edith Mathiowitz (Editor), Donald E. Chickering III (Editor), Claus-Michael Lehr (Editor)

Book Description

ISBN-10: 0824719956 | ISBN-13: 978-0824719951 | Publication Date: July 13, 1999 | Edition: 1

This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs. Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport! Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinical applications, Bioadhesive Drug Delivery Systems · discusses mechanical and chemical bonding, polymer-mucus interactions, the effect of surface energy in bioadhesion, polymer hydration, and mucus rheology · analyzes biochemical properties of mucus and glycoproteins, cell adhesion molecules, and cellular interaction with two- and three-dimensional surfaces · covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell-cell interactions · examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles · describes vaginal, nasal, buccal, ocular, and transdermal drug delivery · reviews bioadhesive interactions with the mucosal tissues of the eye and mouth, and those in the respiratory, urinary, and gastrointestinal tracts · explores issues of product development, clinical testing, and production · and more! Amply referenced with over 1400 bibliographic citations, and illustrated with more than 300 drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an excellent introduction to the subject. This unique reference is ideal for pharmaceutical scientists and technologists; chemical, polymer, and plastics engineers; biochemists; physical, surface, and colloid chemists; biologists; and upper-level undergraduate and graduate students in these disciplines.

Editorial Reviews

Review

This comprehensive, multi-author volume would form an excellent starting point for researchers, students and industrial scientists keen to familiarize themselves with this field.
…This book, a welcome addition to the series Drugs and the Pharmaceutical Sciences, will provide excellent background and, indeed, might almost be regarded as a manual for those working in this areas.
- Retinoids & Lipid-Soluable Vitamins in Clinical Practice

…excellent….
…very interesting and certainly stimulating. The authors and the editors are to be congratulated for providing a valuable and timely review of a new development subject.
-Pharmaceutical Technology

Product Details

• Hardcover: 696 pages
• Publisher: Informa HealthCare; 1 edition (July 13, 1999)
• Language: English
• ISBN-10: 0824719956
• ISBN-13: 978-0824719951
• Product Dimensions: 9.1 x 6.2 x 1.3 inches
• Shipping Weight: 2.7 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #3,191,777 in Books (See Top 100 in Books)
  • #54 in Books > Medical Books > Pharmacology > Drug Delivery Systems