The goal of an activity-directed isolation process is to isolate bioactive compounds which may provide structural leads of therapeutic importance. The traditional process of drug development is long and expensive, but simple and rapid bioassays can serve as the starting point for drug discovery. This book presents a range of "bench top" bioassay techniques useful for natural product and pharmaceutical chemists involved in drug discovery and pharmacognosy. The majority of these bioassays are presented in a step-by-step format, so they could even be implemented by technical personnel with little background in microbiology, biochemistry or pharmacology.
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Inside This Book
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First Sentence:
"Extracts from natural product sources have served as a valuable source of molecular diversity in many drug discovery programs, and several important drugs have been isolated from natural products." Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
heat inactivated foetal bovine serum, time course binding data, functional receptor assays, receptor functional assays, chemistry reaction products, screening natural product extracts, plate scintillation counter, pure natural product, human neutrophil membranes, high throughput functional assays, test sample solution, final assay concentration, made upto, least squares curve fitting program, bioassay screen, fluorescent plate reader, competing compound, radioiodinated ligands, radioligand binding assays, bound radioligand, assay steps, hyaluronidase enzyme, microtiter plate format, containing various concentrations, shrimp larvae Key Phrases - Capitalized Phrases (CAPs): (learn more)
High-Throughput Screening, Male Wistar, San Diego, American Type Culture Collection, Preparation of Reagents New!
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Front Cover | Table of Contents | First Pages | Index | Surprise Me!
"Extracts from natural product sources have served as a valuable source of molecular diversity in many drug discovery programs, and several important drugs have been isolated from natural products." Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
heat inactivated foetal bovine serum, time course binding data, functional receptor assays, receptor functional assays, chemistry reaction products, screening natural product extracts, plate scintillation counter, pure natural product, human neutrophil membranes, high throughput functional assays, test sample solution, final assay concentration, made upto, least squares curve fitting program, bioassay screen, fluorescent plate reader, competing compound, radioiodinated ligands, radioligand binding assays, bound radioligand, assay steps, hyaluronidase enzyme, microtiter plate format, containing various concentrations, shrimp larvae Key Phrases - Capitalized Phrases (CAPs): (learn more)
High-Throughput Screening, Male Wistar, San Diego, American Type Culture Collection, Preparation of Reagents New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Surprise Me!
Citations (learn more)
This book cites 8
books:
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- Bioanalytical Applications of Labeling by Ilkka Hemmila in Back Matter (1), and Back Matter (2)
- Advances in Natural Products Chemistry: Extraction and Isolation of Biologically Active Compounds (Kodansha scientific books) by Sinsaku Natori in Back Matter
- Cell Surface Receptors: A Short Course on Theory and Methods by Lee E. Limbird in Back Matter
- Natural Products Chemistry Volume 3 by Koji Nakanishi in Back Matter
- Neurotransmitter Receptor Binding by Henry I. Yamamura in Back Matter
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