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Biobazaar: The Open Source Revolution and Biotechnology
 
 
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Biobazaar: The Open Source Revolution and Biotechnology [Hardcover]

Janet Hope (Author)
4.0 out of 5 stars  See all reviews (1 customer review)

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Book Description

0674026357 978-0674026353 January 31, 2008

Fighting disease, combating hunger, preserving the balance of life on Earth: the future of biotechnological innovation may well be the future of our planet itself. And yet the vexed state of intellectual property law--a proliferation of ever more complex rights governing research and development--is complicating this future. At a similar point in the development of information technology, "open source" software revolutionized the field, simultaneously encouraging innovation and transforming markets. The question that Janet Hope explores in Biobazaar is: can the open source approach do for biotechnology what it has done for information technology? Her book is the first sustained and systematic inquiry into the application of open source principles to the life sciences.

The appeal of the open source approach--famously likened to a "bazaar," in contrast to the more traditional "cathedral" style of technology development--lies in its safeguarding of community access to proprietary tools without discouraging valuable commercial participation. Traversing disciplinary boundaries, Hope presents a careful analysis of intellectual property-related challenges confronting the biotechnology industry and then paints a detailed picture of "open source biotechnology" as a possible solution. With insights drawn from interviews with Nobel Prize-winning scientists and leaders of the free and open source software movement--as well as company executives, international policymakers, licensing experts, and industry analysts--her book suggests that open source biotechnology is both desirable and broadly feasible--and, in many ways, merely awaiting its moment.


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Editorial Reviews

From Publishers Weekly

Australian biologist and lawyer Hope challenges the "commercialization of life sciences research over the final quarter of the last century" in this rigorous, closely reasoned book. Referencing Thomas Kuhn's groundbreaking volume, The Structure of Scientific Revolutions, Hope takes a hard look at intellectual property law, which currently protects monopolistic corporations' right to inflate prices for "life-saving drugs or life-sustaining new crops." Sensing "a paradigm shift in the values underpinning life sciences research," Hope seeks to readdress these policies by applying the model of open-source software to the biotech field. She finds a keen analogy in the Microsoft-Linux conflict, which ultimately broke Microsoft's monopoly and allowed market forces to operate unhindered, ultimately lifting all ships, and devotes an entire chapter to open source licensing which would end "proprietary exclusivity" while maintaining the principles of intellectual property (permitting use or distribution "for free or for a fee-without having to pay royalties to the licensor"). While the plan seems a stretch-necessitating international agreement to revise existing treaties-Hope is optimistic, providing a provocative, highly intelligent and practical argument on a hot topic; though it's no easy read, policy wonks and scientists will find much to appreciate.
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.

Review

Biobazaar is the first book dedicated to studying current efforts at open biological innovation. It is a well-researched and thoughtful analysis of the great potential that such innovation holds for improving the ways we address some of our most basic human needs.
--Yochai Benkler, author of the Wealth of Networks (20080121)

Can an open-source-style economy in life sciences change the landscape of innovation, and for the better? Hope provides a much-needed, reasoned guide to thinking through that critical question.
--Steven Weber, author of The Success of Open Source

Life Sciences are set to become the driver of 21st century economic and national competitiveness, much as Information technology was at the end of the 20th century. Janet Hope's Biobazaar: The Open Source Revolution and Biotechnology takes on a fundamental question that will determine where innovation happens in biotechnology: Who owns what pieces of intellectual property in this system, and what can they do with what they own? Her thoughtful and non-ideological assessment of the problem leads to a powerful analogy with software and the open source model for producing complex knowledge goods. Can an open source style economy in life sciences change the landscape of innovation, and for the better? Hope provides a much-needed, reasoned guide to thinking through that critical question.
--Steven Weber, author of The Success of Open Source

Are we on the verge of an open source revolution? If not a revolution, surely a growing rebellion. Hope gives us food for thought on the possibilities.
--James Love (New Scientist )

[A] rigorous, closely reasoned book. Referencing Thomas Kuhn's groundbreaking volume, The Structure of Scientific Revolutions, Hope takes a hard look at intellectual property law, which currently protects monopolistic corporations' right to inflate prices for "life-saving drugs or life-sustaining new crops." Sensing "a paradigm shift in the values underpinning life sciences research," Hope seeks to readdress these policies by applying the model of open-source software to the biotech field. (Publishers Weekly )

Product Details

  • Hardcover: 448 pages
  • Publisher: Harvard University Press (January 31, 2008)
  • Language: English
  • ISBN-10: 0674026357
  • ISBN-13: 978-0674026353
  • Product Dimensions: 8.3 x 5.7 x 1.7 inches
  • Shipping Weight: 1.4 pounds (View shipping rates and policies)
  • Average Customer Review: 4.0 out of 5 stars  See all reviews (1 customer review)
  • Amazon Best Sellers Rank: #1,803,575 in Books (See Top 100 in Books)

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6 of 6 people found the following review helpful:
4.0 out of 5 stars Many good ideas, detached presentation (3.5 stars), March 25, 2008
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This review is from: Biobazaar: The Open Source Revolution and Biotechnology (Hardcover)
The author of this book (JH) has used her professional background in both law and biology to produce a comprehensive, closely-reasoned work. Drawing on Eric Raymond's software development dichotomy of "The Cathedral and the Bazaar", she makes a passionate and intriguing case for replacing the hierarchical ("cathedral-building") style of usual corporate biotech R&D with collective, "bazaar"-based production (a/k/a "commons-based peer production" and "horizontally networked user innovation," @109), like that in open source software communities.

It's clear that JH has thought through the pros, cons and implications of open source very thoroughly. In fact, quite apart from biotech, you can learn a lot about the business and legal aspects of open source software from this book. JH also makes many imaginative and potentially fruitful suggestions about how open source biotech tools could be exploited to help address tropical diseases, or be of use to (and perhaps be financed by) generic pharmaceutical firms, for example. Throeughtout, she pays attention not only to "red", health-related biotech, but also "green", agricultural biotech (albeit omitting "white" biotech, for industrial applications).

That the successes of open source biotech to date have been few and far between, and have largely related to IT or digital content rather than to "wet" technology, does take some of the fizz out of the topic by the end of the book. But there's still a lot of interesting content buried here, and as for applying it, maybe someday someone might get it right.

If you're interested in intellectual property, a book like this could be exciting and stimulating. Unfortunately, this book falls short of that. The reason is the presentation, which has weaknesses at several levels. Starting at the most literal one, the book reads like a re-purposed Ph.D. dissertation, full of roadmap talk for disoriented senior faculty ("At the start of the last chapter, I highlighted ... So far this chapter has focused on ... In answering these objections I have argued..." -- all in one paragraph @ 218). The chapter subsections are rather long, and tend to contain lists of factors, arguments, reasons, etc. that are analyzed in turn; these actually could have benefitted from more formatting, such as numbering or captioning.

A bit deeper, there's the problem of jargon. The typical reader is assumed never to have negotiated a licensing deal in his or her life; deal terms and the sensitivities of each are explained nicely in the early chapters. However, he or she *is* assumed to be familiar with the usual jargon of the "law and economics" approach to IP; terms like "rents" and "transaction costs" are thrown around long before they are defined (if ever). Most proponents of L&E are too young to realize how recently this way of looking at law has come into vogue, and how irrelevant it is to the practical business world. Believe me, one can profitably spend decades doing IP transactions, and a bit of patent prosecution, without ever needing to think of patents as "a way of preempting market failure resulting from the 'free rider' problem" (@71), or worrying about transaction costs or even "governance" (@109ff). Even worse, most references to biotech technologies are inadequately explained, such as "germplasm", "GURTs" and "diversity arrays technology".

The unexplained jargon is symptomatic of the abstract style of JH's presentation. How is a reader supposed to sink his or her teeth into a sentence like "[A]t least one agricultural biotechnology firm has made a modest success of exploiting a patented platform technology using an open-source-like nonproprietary strategy" (@272) if none of the company, the technology nor the strategy are named? Although a few companies are named, especially in the last couple of chapters, vague generality is more the rule than the exception.

Most unfortunately, the abstraction morphs into detachment. When JH mentions, e.g., that IP can "make traditional agricultural practices such as the saving of seeds difficult or impossible" (@102), she never shifts her gaze from the "practice" to the people who practice it, or their plight. Or consider a description of a paper arguing that Bayh-Dole "has created a misalignment of university technology transfer offices and public interests that benefit the the innovation system at large and enable access to intellectual property rights for humanitarian purposes" (@275). Within the confusing, albeit parsable, sytntax, JH focuses on the benefits (or lack of same) to "the innovation system" through access to "rights". What the book all too rarely mentions is an interest in benefiting *people* through improved access to *stuff*.

By the end of 330-odd pages of main text, the reader has slogged through a litany of theorists, countless arguments, counter-arguments and refutations, and innumerable narratives about costs. You can also learn something about how open source biotech could, in theory, make life more fun or profitable for people engaged in biotech research and product development. If you're interested in learning how it might benefit sick or hungry people, though, that's left entirely to your imagination: such folks don't merit a mention in this book. One hopes they are JH's main concern too; but if so, she's done a poor job of communicating it.

PS (2008/04/13): Shortly after posting this review, I had some very gracious feedback from JH. Based on our correspondence, it seems she does share the concrete social concerns, as well as an awareness of the drawbacks of an abstracted style, mentioned above. Since that input is an "externality" to this book, I haven't modified my review beyond adding a postscript. But it does make me look forward to her next one.
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Inside This Book (learn more)
First Sentence:
Early in the new millennium, ten years after completing an undergraduate degree in biochemistry and molecular biology, I returned to the classroom for a refresher course. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
biotechnology freedom, open source biotechnology, nonproprietary strategies, bazaar governance, bazaar production, nonproprietary exploitation strategies, proprietary exclusivity, biotechnology licenses, biotechnology licensors, copyleft obligation, nonproprietary strategy, open source licensors, open source software context, license proliferation, source drug development, biotechnology licensing, enhanced use value, open source production, biotechnology setting, information stickiness, biotechnology context, anticommons tragedy, free revealing, open source software licensing, open source terms
Key Phrases - Capitalized Phrases (CAPs): (learn more)
United States, Financing Open Source Biotechnology, Fair Trade, Bayh-Dole Act, Creative Commons, The Wealth of Networks, Human Genome Project, Steven Weber, General Public License, Equitable Access, Richard Stallman, Bruce Perens, Eric Raymond, Yochai Benkler, Diversity Arrays Technology, Biotechnology Research
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Front Cover | Table of Contents | First Pages | Index | Surprise Me!
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