Biochemical Oscillations and Cellular Rhythms: The Molecular Bases of Periodic and Chaotic Behaviour [Paperback]

Albert Goldbeter (Author), M. J. Berridge (Foreword)

Book Description

Publication Date: April 13, 1997 | ISBN-10: 0521599466 | ISBN-13: 978-0521599467

This book addresses the molecular bases of some of the most important biochemical rhythms known at the cellular level. The approach rests on the analysis of theoretical models closely related to experimental observations. Among the main rhythms considered are glycolytic oscillations observed in yeast and muscle, oscillations of cyclic AMP in Dictyostelium amoebae, intracellular calcium oscillation observed in a variety of cell types, the mitotic oscillator that drives the cell division cycle in eukaryotes, pulsatile hormone signaling, and circadian rhythms in Drosophila. This book will be of interest to life scientists such as biochemists, cell biologists, chronobiologists, medical scientists and pharmacologists. In addition, it will appeal to scientists studying nonlinear phenomena, including oscillations and chaos, in chemistry, physics, mathematics and theoretical biology.

Editorial Reviews

Review

"The book beautifully illustrates the art of modeling...It is an excellent read and will appeal to a wide ranging audience..." Philip K. Maini, Trends in Biochemical Sciences

"A scintillating book...The importance of its contribution to the field is crystal clear." Ernst Knobil, University of Texas Health Science Center, Houston

"...a very impressive tome and is a superb addition to the literature. It is quite clearly going to be the reference book on oscillations." James D. Murray, University of Washington, Seattle

"Albert Goldbeter...is a reliable guide through the intricacies of the biochemistry and mathematics...The great strength of the book is his unshrinking dedication to understanding these processes from start to finish...the book is conversational, clear, and accurate...The only way to understand these biological rhythms...is to become more quantitative and to develop rigorous mathematical models. Albert Goldbeter is at the very forefront of this new approach." John J. Tyson, Nature

"...will not only serve as a guide to the most interesting questions in the field of rhythms, chaos and nonlinear models but also open up new research themes. It is of interest for a wide audience of chemists, physicists, biologists, medical scientists and mathematicians who look for interesting application fields....a source of sustained intellectual joy." Andreas Deutsch, Biomathematics Newsletter

"...contains an impressive compilation of the literature in the field....will undoubtedly become a classic in the field of mathematical modelling of cellular processes....I will enjoy having the book on my bookshelf for consultation, and I am confident that it will serve me well for many years." Lars Folke Olsen, Bulletin of Mathematical Biology

"[The book]...will be of value to chemists and mathematicians who are interested in the biological applications of their field. It provides a comprehensive account of a new field and makes it abundantly clear that this is only the beginning of what might be a means of brininging together areas that have, until now, seemed rather far apart. I recommend this book for its data, its approach, its ideas, and for the way in which it introduces the whole concept of oscillation in biological systems." Jim M. Waterhouse, BioEssays

Language Notes

Text: English (translation)
Original Language: French --This text refers to an out of print or unavailable edition of this title.

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Product Details

• Paperback: 632 pages
• Publisher: Cambridge University Press (April 13, 1997)
• Language: English
• ISBN-10: 0521599466
• ISBN-13: 978-0521599467
• Product Dimensions: 9 x 6.1 x 1.4 inches
• Shipping Weight: 2.2 pounds (View shipping rates and policies)
• Average Customer Review: 5.0 out of 5 stars  See all reviews (1 customer review)
• Amazon Best Sellers Rank: #2,323,555 in Books (See Top 100 in Books)

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Most Helpful Customer Reviews

5 of 6 people found the following review helpful:

5.0 out of 5 stars Great book on non-linear dynamics of metabolic pathways, March 10, 2006

By 

Mr. Ariosto Silva - See all my reviews
(REAL NAME)   

This review is from: Biochemical Oscillations and Cellular Rhythms: The Molecular Bases of Periodic and Chaotic Behaviour (Paperback)

Albert Goldbeter wrote in the 70s the first articles with models on the oscillations that arise from positive feed-back regulation on metabolic pathways and since then much work has been done by him and other groups on the non-linear behavior of these systems.

This book has great chapters such as the one decribing the transitions the glycolytic pathway can suffer when some biological parameters are modified, varying from a steady-state metabolic flux to an oscillatory, complex or even chaotic one.

The math is quite advanced and in order to fully understand the consequences withdrawn from the models the reader will need a good knowledge of calculus more specifically of systems of non-linear differential equations.

In order to get full advantage of this book I would recommend fetching his early articles in pubmed with the numerical parameters for the equations as well as implementing these models in Matlab or Mathematica.