Genome- and proteome-based research is generating a significant increase in the number of available drug targets. Correspondingly there is an increasing need for novel, diverse compounds, particularly based on natural compounds, as screening resource. The purpose of the Ernst Schering Research Foundation Workshop 51 was to provide a forum for an open exchange on perspectives and limitations of biocombinatorial synthesis and the significance of this technology for future drug discovery in light of this challenge. Experts from academia and industry provided contributions covering: the significance of natural compounds for state-of-the-art drug discovery; the underlying basic principle for the biosynthesis of highly complex compounds; and the scope and limitations of combinatorial biosynthesis regarding formation, identification, optimisation, isolation and manufacturing of novel biologically active entities.
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hybrid synthetases, halogenating activity, halogenating enzymes, glycopeptide biosynthesis, yersiniabactin synthetase, pyrrolnitrin biosynthesis, biocombinatorial approaches, biosynthetic gene cluster, polyketide synthase modules, tailoring enzymes, combinatorial biosynthesis, erythromycin polyketide synthase, penicillin biosynthetic pathway, alcohol stereochemistry, intermodular communication, novel glycopeptides, modular polyketide synthases, docking domains, metabolite balancing, nonribosomal peptide synthetases, central carbon metabolism, polyketide biosynthesis, nonribosomal peptide synthesis, thioesterase domain, sugar biosynthesis Key Phrases - Capitalized Phrases (CAPs): (learn more)
Chem Biol, Biol Chem, Proc Natl Acad Sci, Nat Prod, Mol Microbiol, Mol Gen Genet, Mol Biol, Nat Biotechnol, Liu H-w, Microbiol Lett, New York, Antimicrob Agents Chemother, Angew Chem Int Ed Engl, Enzymatic Incorporation of Halogen Atoms, Annu Rev Microbiol, Appl Environ Microbiol, Appl Microbiol Biotechnol, Del Vecchio, Detected Detected Detected, Nat Struct Biol, Nucl Acids Res, Annu Rev Biochem, Bioorg Med Chem Lett, Biotechnol Bioeng, Combinature Biopharm New!
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hybrid synthetases, halogenating activity, halogenating enzymes, glycopeptide biosynthesis, yersiniabactin synthetase, pyrrolnitrin biosynthesis, biocombinatorial approaches, biosynthetic gene cluster, polyketide synthase modules, tailoring enzymes, combinatorial biosynthesis, erythromycin polyketide synthase, penicillin biosynthetic pathway, alcohol stereochemistry, intermodular communication, novel glycopeptides, modular polyketide synthases, docking domains, metabolite balancing, nonribosomal peptide synthetases, central carbon metabolism, polyketide biosynthesis, nonribosomal peptide synthesis, thioesterase domain, sugar biosynthesis Key Phrases - Capitalized Phrases (CAPs): (learn more)
Chem Biol, Biol Chem, Proc Natl Acad Sci, Nat Prod, Mol Microbiol, Mol Gen Genet, Mol Biol, Nat Biotechnol, Liu H-w, Microbiol Lett, New York, Antimicrob Agents Chemother, Angew Chem Int Ed Engl, Enzymatic Incorporation of Halogen Atoms, Annu Rev Microbiol, Appl Environ Microbiol, Appl Microbiol Biotechnol, Del Vecchio, Detected Detected Detected, Nat Struct Biol, Nucl Acids Res, Annu Rev Biochem, Bioorg Med Chem Lett, Biotechnol Bioeng, Combinature Biopharm New!
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7
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- Opportunities and Challenges of the Therapies Targeting CNS Regeneration (Ernst Schering Foundation Symposium Proceedings) by H.D. Perez in Back Matter
- New Mechanisms for Tissue-Selective Estrogen-Free Contraception (Ernst Schering Foundation Symposium Proceedings) by H.B. Croxatto in Back Matter
- Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases (Ernst Schering Foundation Symposium Proceedings) by R. Numerof in Back Matter
- The Histone Code and Beyond: New Approaches to Cancer Therapy (Ernst Schering Foundation Symposium Proceedings) by Shelley L. Berger in Back Matter
- Von der Wahrnehmung zur Erkenntnis - From Perception to Understanding: Symposium der Schering Forschungsgesellschaft zu Ehren von Prof. Dr. Dr. h.c. ... Supplements) (German and English Edition) by Monika Lessl in Back Matter
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