This comprehensive volume provides a state-of-the-art perspective on methodological considerations in the use of biological markers in epidemiologic studies. The text discusses the use of biological markers for evaluation, biological responses, biologically effective dosage, internal dose, and susceptibility; methodological issues such as classification, sensitivity, stability, variability, and confounding variables are thoroughly examined. The characteristics of several specific classes of markers, such as sister-chromatid-exchange, protein and DNA adducts, micronuclei, urine mutagenicity assays, chromosome aberrations and oncogenes are described. Markers of susceptibility such as N-acetyltransferase are also discussed. Effective sample collection procedures, sensitive and specific assays for detection of the marker in the medium of choice are given careful consideration, as are the methodological issues applicable to epidemiologic studies.
Book Description
Editorial Reviews
Review
"Achieves its objective as an introductory text for epidemiologists . . . . The importance of linking environmental causes of cancer and other diseases with molecular events is so great that every research opportunity should be explored. This book should help facilitate communication between epidemiologists and laboratory scientists and is thus an important contribution toward this goal." --Cancer Cells
"It is quite well written and I expect that it will be a landmark publication. It is apparent that strong efforts were made to express complicated concepts and terms of molecular biology in a way that most epidemiologists will be able to comprehend . . . . This is a marvelous effort." --Paul A. Schulte, Ph.D.
"This book should provide epidemiologists with a basic understanding of the assays currently available, and provide laboratory scientists with an understanding of the methodological issues facing epidemiologists in this field. It takes a first step in bringing together these two groups, a necessity for the successful application of these new methodologies to epidemiologic studies." --The Quarterly Review of Biology
"An important book for human biologists. . . .Methods are presented in a clear manner. . . .There are many useful tables and figures." --American Journal of Human Biology
"This is an excellent thought-provoking book though some selective reading of the more labratory oriented chapters may be preferable, depending on the epidemiological reader's field of interest." --International Journal of Epidemiology
""[The book] is written with the expressed purpose of improving communication and collaboration between laboratory investigators and epidemiologists in this rapidly emerging field. Recommended for epidemiologists, occupational and environmental health professionals with an interest in the field." --ASHA Occupational Health and Safety Newsletter
"Achieves its objective as an introductory text for epidemiologists.... The importance of linking environmental causes of cancer and other diseases with molecular events is so great that every research opportunity should be explored. This book should help facilitate communication between epidemiologists and laboratory scientists and is thus an important contribution toward this goal." --Cancer Cells
"It is quite well written and I expect that it will be a landmark publication. It is apparent that strong efforts were made to express complicated concepts and terms of molecular biology in a way that most epidemiologists will be able to comprehend.... This is a marvelous effort." --Paul A. Schulte, Ph.D.
"An important book for human biologists.... Methods are presented in a clear manner.... There are many useful tables and figures." --American Journal of Human Biology
"This is an excellent thought-provoking book though some selective reading of the more laboratory oriented chapters may be preferable, depending on the epidemiological reader's field of interest." --International Journal of Epidemiology
"It is quite well written and I expect that it will be a landmark publication. It is apparent that strong efforts were made to express complicated concepts and terms of molecular biology in a way that most epidemiologists will be able to comprehend . . . . This is a marvelous effort." --Paul A. Schulte, Ph.D.
"This book should provide epidemiologists with a basic understanding of the assays currently available, and provide laboratory scientists with an understanding of the methodological issues facing epidemiologists in this field. It takes a first step in bringing together these two groups, a necessity for the successful application of these new methodologies to epidemiologic studies." --The Quarterly Review of Biology
"An important book for human biologists. . . .Methods are presented in a clear manner. . . .There are many useful tables and figures." --American Journal of Human Biology
"This is an excellent thought-provoking book though some selective reading of the more labratory oriented chapters may be preferable, depending on the epidemiological reader's field of interest." --International Journal of Epidemiology
""[The book] is written with the expressed purpose of improving communication and collaboration between laboratory investigators and epidemiologists in this rapidly emerging field. Recommended for epidemiologists, occupational and environmental health professionals with an interest in the field." --ASHA Occupational Health and Safety Newsletter
"Achieves its objective as an introductory text for epidemiologists.... The importance of linking environmental causes of cancer and other diseases with molecular events is so great that every research opportunity should be explored. This book should help facilitate communication between epidemiologists and laboratory scientists and is thus an important contribution toward this goal." --Cancer Cells
"It is quite well written and I expect that it will be a landmark publication. It is apparent that strong efforts were made to express complicated concepts and terms of molecular biology in a way that most epidemiologists will be able to comprehend.... This is a marvelous effort." --Paul A. Schulte, Ph.D.
"An important book for human biologists.... Methods are presented in a clear manner.... There are many useful tables and figures." --American Journal of Human Biology
"This is an excellent thought-provoking book though some selective reading of the more laboratory oriented chapters may be preferable, depending on the epidemiological reader's field of interest." --International Journal of Epidemiology
About the Author
Barbara S. Hulka, Chairman of Epidemiology, University of North Carolina. Timothy C. Wilcosky, Professor of Epidemiology, University of North Carolina. Jack D. Griffith, Senior Epidemiologist, US Environmental Protection Agency.
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