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Biology Is Technology: The Promise, Peril, and New Business of Engineering Life [Hardcover]

Robert H. Carlson
4.2 out of 5 stars  See all reviews (5 customer reviews)


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Book Description

February 25, 2010 0674035445 978-0674035447

Technology is a process and a body of knowledge as much as a collection of artifacts. Biology is no different—and we are just beginning to comprehend the challenges inherent in the next stage of biology as a human technology. It is this critical moment, with its wide-ranging implications, that Robert Carlson considers in Biology Is Technology. He offers a uniquely informed perspective on the endeavors that contribute to current progress in this area—the science of biological systems and the technology used to manipulate them.

In a number of case studies, Carlson demonstrates that the development of new mathematical, computational, and laboratory tools will facilitate the engineering of biological artifacts—up to and including organisms and ecosystems. Exploring how this will happen, with reference to past technological advances, he explains how objects are constructed virtually, tested using sophisticated mathematical models, and finally constructed in the real world.

Such rapid increases in the power, availability, and application of biotechnology raise obvious questions about who gets to use it, and to what end. Carlson’s thoughtful analysis offers rare insight into our choices about how to develop biological technologies and how these choices will determine the pace and effectiveness of innovation as a public good.



Editorial Reviews

Review

Biology is Technology makes a tremendous contribution to public analysis of a very important emerging field. Although various commentators have discussed particular aspects of synthetic biology (e.g. risk regulation, intellectual property considerations), I am not aware of a book that encapsulates all of the varying strands of the debate. In addition, the book takes a set of provocative and interesting stances on the subjects that it addresses. It is obviously written by someone who has been a longstanding participant in, and commentator on, the field. Although I do not necessarily agree with all of the positions taken by the book, they are well-defended and thought through.
--Arti K. Rai, Elvin R. Latty Professor of Law, Duke Law School

Carlson clearly frames a fresh future for biotechnology. Each chapter, from technology trends to property rights and biosecurity conundrums, invites close reading and vibrant discussion.
--Drew Endy, Stanford Bioengineering & The BioBricks Foundation

Since Rob Carlson is THE authoritative tracker of progress in biotech, this book is the most complete---and exciting&mdashchronicle&mdash of the technological revolution that promises to dominate this century.
--Stewart Brand, Author of Whole Earth Discipline: An Ecopragmatist Manifesto

In this new book, bioengineer Robert H. Carlson forecasts the rise of the cell and the subsequent emergence of biological techniques for making fuels, synthetic DNA that builds new organisms, and reverse-engineered viruses for making vaccines. Biologists, Carlson says, are the new engineers, and the future is in remodeling life as we know it. (Wired 20100301)

[Carlson] presents an informative view of the future prospects for biotechnology and its regulation.
--Michael A. Goldman (Nature 20100422)

Biology Is Technology is essential reading for anyone who wishes to understand the current state of biotechnology and the opportunities and dangers it may create.
--Alex Soojung-Kim Pang (American Scientist 20101101)

A thoughtful attempt to put what we think we know about biotechnology into a larger context, by a physicist-turned-bioentrepreneur. (The Economist 20101204)

About the Author

Robert H. Carlson is a Principal at Biodesic LLC.

Product Details

  • Hardcover: 288 pages
  • Publisher: Harvard University Press (February 25, 2010)
  • Language: English
  • ISBN-10: 0674035445
  • ISBN-13: 978-0674035447
  • Product Dimensions: 6.1 x 1 x 9.2 inches
  • Shipping Weight: 1.2 pounds
  • Average Customer Review: 4.2 out of 5 stars  See all reviews (5 customer reviews)
  • Amazon Best Sellers Rank: #1,320,512 in Books (See Top 100 in Books)

More About the Author

Dr. Rob Carlson is a Principal at Biodesic, an engineering, consulting, and design firm in Seattle. At the broadest level, Rob is interested in the future role of biology as a human technology. He has worked to develop new biological technologies in both academic and commercial environments, focusing on molecular measurement and microfluidic systems. Carlson is the author of the book Biology is Technology: The Promise, Peril, and New Business of Engineering Life, published in 2010 by Harvard University Press. Rob earned a doctorate in Physics from Princeton University in 1997.

From 2002 to 2007, Dr. Carlson was a Senior Scientist in the Electrical Engineeering department at the University of Washington. From 2003 to 2008, he provided technology analysis and strategic consulting as a Senior Associate at Bio-Economic Research Associates (Bio-era), writing extensively on pandemic preparedness, synthetic vaccines, biofuels, and biological technologies, and presenting briefings on these subjects to executives and government officials around the world. From 1997 to 2002 he was a Research Fellow at The Molecular Sciences Institute in Berkeley, CA.

Links to additional articles and a weblog can be found at http://www.synthesis.cc .

Customer Reviews

4.2 out of 5 stars
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Most Helpful Customer Reviews
9 of 9 people found the following review helpful
5.0 out of 5 stars The first of the small-scale biotech company books. March 23, 2010
Format:Hardcover|Amazon Verified Purchase
Book was review of recent adventures in open-source and small scale biotechnology. If you haven't been reading the scholarly literature on devices and breakthroughs, I can think of no better crash course.

From Keasling's entire engineered metabolic pathways to iGEM to Amyris's new fuel producing bacteria, the author has an excellent and informed perspective on the breakthroughs that are worth thinking about.

The author also describes in detail the difficult morass of patent and copyright law concerning biotechnology. His description of CAMBIA's "walled garden" is better than any I have read, even in books exclusively about open-source biotechnology. (Although there is currently only one, Biobazaar).

His description of garage biotechnology is sparse, mainly due to the above morass, and it would have been nice to have more details on the LavaAmp, this author's most recent work, which is a very cheap, reusable PCR device.

This book goes by fast, and is a must read for anyone looking to start or invest in a small biotechnology company, or anyone who wants to do it themselves.
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8 of 9 people found the following review helpful
5.0 out of 5 stars Excellent March 15, 2010
Format:Hardcover|Amazon Verified Purchase
Excellent survey of recent developments AND a thorough argument that openness contributes more to our safety from future attacks and accidents than trying to restrict knowledge and materials could. Not quite up to date, as he wrote in the Afterword, "everyone in the field is running so fast that it is impossible to keep up", but more so than any other book I have found. Most of the detailed discussion of the actual technology is up to about 2 years ago. A good discussion of the benefits and problems of patents as they apply to biotechnology (and to any field where many patents may apply to a single product (patent thickets)). Surprisingly readable for the amount of information included.
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2 of 2 people found the following review helpful
Format:Paperback|Amazon Verified Purchase
Biology Is Technology is written like a quality research paper. It covers the current challenges with delivering bioengineering/biotechnology solutions and what is being done to meet those challenges. This is a no BS book. Carlson goes into the meat right off the bat, and you are not likely to be disappointed with any of the chapters by the time you finish. If you are an investor, entrepreneur, executive, or are just curious, this book needs to be on your bookshelf.

Table of Contents:

1. What Is Biology?
2. Building with Biological Parts
3. Learning to Fly (or Yeast, Geese, and 747s)
4. The Second Coming of Synthetic Biology
5. A Future History of Biological Engineering
6. A Pace of Change in Biological Technologies
7. The International Genetically Engineered Machines Competition
8. Reprogramming Cells and Building Genomes
9. The Promise and Peril of Biological Technologies
10. The Sources of Inspiration and the Effects of Existing and Proposed Regulations
11. Laying the Foundations for a Bioeconomy
12. Of Straitjackets and Springboards for Innovation
13. Open-Source Biology, or Open Biology?
14. What Makes a Revolution?
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