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Biomolecular Crystallography: Principles, Practice, and Application to Structural Biology [Hardcover]

Bernhard Rupp
4.9 out of 5 stars  See all reviews (8 customer reviews)

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Book Description

October 20, 2009 0815340818 978-0815340812 1

Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography.  Deftly illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. It distills key concepts for understanding the practice and analysis of protein crystal structures and contains examples of biologically-relevant molecules, complexes, and drug target structures.

Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.


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Biomolecular Crystallography: Principles, Practice, and Application to Structural Biology + Crystallography Made Crystal Clear, Third Edition: A Guide for Users of Macromolecular Models (Complementary Science)
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Editorial Reviews

Review

PRAISE FOR Biomolecular Crystallography:

"Over the past 34 years Louise and I have often discussed the possibility of updating [Protein Crystallography]....However, this marvelous text by Bernhard Rupp provides everything that we could have done and more: indeed all that is required for the student of 2010. Biomolecular Crystallography is an impressive volume. Its 808 pages are beautifully written and wonderfully illustrated, many in colour....This book will be an essential part of the library of any department that claims to make contributions to modern biology....[and] a necessary addition also to the libraries of big pharmaceutical companies and small biotechs. This is a book to be enjoyed by all who wish to become structural biologists. I am also sure that many practicing structural biologists - even some who consider themselves mature - would do well to read its pages." - Tom Blundell, Journal of Applied Crystallography

"It is a masterpiece. It is the book which the MX community has been waiting for and it is an absolute must-have for everybody in the field." - Acta Crystallographica

"This is the book that molecular biologists and the crystallographic community have been waiting for." - Alexander McPherson, University of California at Irvine, USA

'Biomolecular Crystallography is first and foremost a comprehensive reference text and laboratory manual for the practicing structural biologist, from the basics of biomolecular structure to modern advanced and powerful techniques in biomolecular structure determination, and analysis and application of structural information. Figures and graphs computed from new and original data are used extensively to help clarify important concepts, and derivations of all relevant mathematical and statistical principles—many of which have never been brought together in a single volume—are presented. This fulfils a long-felt need!' - Ian J. Tickle, Astex Therapeutics, Cambridge, UK

'This thorough treatment of modern macromolecular X-ray crystallography combines a comprehensive coverage of the fundamentals with methodological details that are often omitted in introductory texts. It will be of value to anyone that works in macromolecular X-ray crystallography, particularly to graduate students or postdoctoral fellows who are mastering the technique.' - Mark Wilson, University of Nebraska, USA

'Given the extraordinary progress in biomolecular crystallography, the challenge of providing a comprehensive and authoritative overview, starting from first principles, is formidable. Dr Rupp has, however, succeeded admirably.' - Brian Matthews, University of Oregon, USA

 

 

From the Author

For those who complained about the weight - it is here now: Corrected second e-printing/Kindle edition includes all corrections from the errata page up to mid-2012 - pls see BMC errata page on my web site for details.

Best wishes for your crystallography studies,
BR

Product Details

  • Hardcover: 800 pages
  • Publisher: Garland Science; 1 edition (October 20, 2009)
  • Language: English
  • ISBN-10: 0815340818
  • ISBN-13: 978-0815340812
  • Product Dimensions: 10.6 x 8.7 x 1.6 inches
  • Shipping Weight: 4.1 pounds (View shipping rates and policies)
  • Average Customer Review: 4.9 out of 5 stars  See all reviews (8 customer reviews)
  • Amazon Best Sellers Rank: #496,776 in Books (See Top 100 in Books)

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Customer Reviews

Most Helpful Customer Reviews
5 of 5 people found the following review helpful
Format:Hardcover
Macromolecular structure determination, which encompasses crystallographic pursuits undertaken from the mid-1930s to the present, has yielded scientific discoveries often considered to be the cornerstone upon which our understanding of the fundamentals of life can be built. As the technology and information renaissance has evolved, the spotlight has been cast upon the need for a deeper understanding of the mysteries locked within the structure of macromolecular systems and for knowledgeable and astute practitioners of diffraction science whom hold the keys to unlock those secrets. In order to properly train the next generation of structural biologists educated in crystallography, it is essential to have a modern reference volume which deftly unites the various topics critical to this field of science. Such a need has been addressed by Biomolecular Crystallography, which not only focuses on the key elements essential for any crystallographic textbook, such as crystal growth, the physics of diffraction, symmetry, the phase problem, model building, refinement and validation, but also includes information useful for the practicing structural biologist, such as protein production and engineering, bioinformatics and structure-based drug design.

As a crystallographer myself, I was especially intrigued by the organization of the volume which is reminiscent of a crystallographic structural determination. The books thirteen chapters, further arranged into five parts, cover various topics as one proceeds from a protein sequence to a crystal, the fundamentals of protein crystallography, data collection, structure determination and interpreting your structure.
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2 of 2 people found the following review helpful
5.0 out of 5 stars the best overall review of crystallography you can find October 30, 2012
Format:Hardcover
As a budding crystallographer reading every book i could put my hands on in preparation for my dissertation and PhD defense, this was the best book I found by leaps and bounds. Now I'm at a research institute that specializes in crystallography and it is the text for their classes.
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1 of 1 people found the following review helpful
5.0 out of 5 stars Simply love it October 26, 2013
Format:Hardcover|Verified Purchase
I have nothing to say about this book except that it is just PERFECT! I love the structure of the book, the way it is written in order to make it easy to read even for beginners (like me) in macromolecular crystallography.
I definitely give it 5 stars!
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1 of 1 people found the following review helpful
5.0 out of 5 stars So far great book June 18, 2013
Format:Kindle Edition|Verified Purchase
Yet I have to admit I am not yet completely done with it. The author has wonderful understanding of the subject and he presents it clearly for a biochemist, albeit non- crystallographer.
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