Bioorganic and Medicinal Chemistry of Fluorine [Hardcover]

Jean-Pierre Bégué (Author), Daniele Bonnet-Delpon (Author)

Book Description

Publication Date: May 27, 2008 | ISBN-10: 0470278307 | ISBN-13: 978-0470278307 | Edition: 1

Provides a thorough overview of the role of fluorine in pharmaceutical science and development

Includes chapters on fluorinated analogues of natural products, fluorinated amino acids and peptides, and derivatives of sugars

Classifies marketed and in-development fluorinated pharmaceuticals according to their therapeutic classes

Editorial Reviews

Review

"This is an excellent book for those contemplating incorporation of fluorine into their drug design research investigations and how it can be accomplished. It is also an excellent reference book for experts in the area. I enthusiastically recommend adding this to both individual and library collections." (Journal of Medicinal Chemistry, December 25, 2008)

"The book is clearly written and has been adequately translated … .Its compact size, and abundance of helpful schemes, figures, tables and structures make it convenient aid for the practicing scientist." (Journal of the American Chemical Society, December 31, 2008)

"I am pleased to recommend Bioorganic and Medicinal Chemistry of Fluorine as an invaluable reference source and stimulus to further research, for pharmaceutical and medicinal chemists, organic chemists, and biochemists in academia and industry, and for advanced students and instructors in these fields." (Angewandte Chemie, October 13, 2008)

From the Back Cover

The diverse applications of fluorine in bioorganic and medicinal chemistry

The discovery of fluorouracil, fluorocorticoids, and fluoroquinolones has led to expanded interest in and usage of fluorine in chemistry. The first comprehensive reference dedicated to detailing the influence of fluorine on the structural properties of a molecule and on a molecule's biological behavior, Bioorganic and Medicinal Chemistry of Fluorine uses examples of fluorinated drugs to provide a thorough overview of the role of fluorine in pharmaceutical science and development. Covering established drugs as well as innovative and promising ideas, it includes:

• An introduction to the structural, physical, and chemical properties of fluorinated compounds and their preparations

• An examination of fluorinated analogues of natural products, fluorinated amino acids and peptides, and saccharidic derivatives

• A discussion of the inhibition of enzymes by fluorinated compounds

• An overview of existing fluorinated pharmaceuticals as well as some in development, categorized according to their therapeutic classes

Complete with references for further study, this is the premier resource on fluorine for pharmaceutical and medicinal chemists in academia and industry, researchers in organic chemistry and biochemistry, and advanced students and educators in pharmaceutical and medicinal chemistry, biochemistry, and organic chemistry.

See all Editorial Reviews

Product Details

• Hardcover: 366 pages
• Publisher: Wiley-Interscience; 1 edition (May 27, 2008)
• Language: English
• ISBN-10: 0470278307
• ISBN-13: 978-0470278307
• Product Dimensions: 6.5 x 0.8 x 9.4 inches
• Shipping Weight: 1.5 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #2,618,466 in Books (See Top 100 in Books)

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