Focusing on group sequential procedures, summarizes the sequential statistical methods used in anticancer, antiviral, cardiovascular, and gastrointestinal drug research and screening. The clinical and preclinical applications are mainly presented as case studies, many of which form part of New Drug
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Since Sir Austin Bradford Hill in 1946 introduced the controlled clinical trial for the Streptomycin in Tuberculosis Trials Committee of the Medical Research Council (1948), the use of double-blind, randomized, and controlled clinical trials has emerged as a principal method for the evaluation of new drugs or therapeutic procedures in medicine. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
stagewise designs, average sample size reduction, sample size reestimation, combined therapy regimen, dose allocation, following group sequential tests, boundary significance level, experimental treatment arm, group sequential boundaries, adaptive design approach, toxicological judgment, group sequential methods, total mortality data, use function approach, group sequential plans, group sequential approach, group sequential clinical trials, group sequential boundary, ganciclovir group, stochastic curtailing, third interim analysis, group sequential designs, probit model fit, interim look, group sequential trials Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Controlled Clin, Helsinki Heart Study, United States, Norwegian Multicenter Study, Merck Sharp, United Kingdom, Theory Methods, Burroughs Wellcome, New Jersey, Safety Monitoring Committee, Chronic Dis, Dohme Research Laboratories, Marcel Dekker, Mayo Clinic, Blood Institute, National Heart, Analgesic Drug Preference, Cancer Chemother, Peto-Prentice Wilcoxon, Ulcer Status of Completed Prophylaxis Patients, Ann Arbor, Clinical Developments, Digestive Disease Week, Institute of Mathematical Statistics New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Since Sir Austin Bradford Hill in 1946 introduced the controlled clinical trial for the Streptomycin in Tuberculosis Trials Committee of the Medical Research Council (1948), the use of double-blind, randomized, and controlled clinical trials has emerged as a principal method for the evaluation of new drugs or therapeutic procedures in medicine. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
stagewise designs, average sample size reduction, sample size reestimation, combined therapy regimen, dose allocation, following group sequential tests, boundary significance level, experimental treatment arm, group sequential boundaries, adaptive design approach, toxicological judgment, group sequential methods, total mortality data, use function approach, group sequential plans, group sequential approach, group sequential clinical trials, group sequential boundary, ganciclovir group, stochastic curtailing, third interim analysis, group sequential designs, probit model fit, interim look, group sequential trials Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Controlled Clin, Helsinki Heart Study, United States, Norwegian Multicenter Study, Merck Sharp, United Kingdom, Theory Methods, Burroughs Wellcome, New Jersey, Safety Monitoring Committee, Chronic Dis, Dohme Research Laboratories, Marcel Dekker, Mayo Clinic, Blood Institute, National Heart, Analgesic Drug Preference, Cancer Chemother, Peto-Prentice Wilcoxon, Ulcer Status of Completed Prophylaxis Patients, Ann Arbor, Clinical Developments, Digestive Disease Week, Institute of Mathematical Statistics New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
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52
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- Sequential Analysis (Dover Phoenix Editions) by Abraham Wald on 4 pages
- Biopharmaceutical Statistics for Drug Development (Statistics: A Series of Textbooks and Monographs) by Karl E. Peace on 4 pages
- New Jersey: With an Historical Guide (The States and the Nation series) by T. Fleming on page 188, and page 219
- Statistical Methods for Engineers and Scientists (Statistics: A Series of Textbooks and Monographs) by Robert M. Bethea in Front Matter (1), and Front Matter (2)
- Statistics and Society (Statistics: A Series of Textbooks and Monographs) by Federer in Front Matter (1), and Front Matter (2)
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- Epidemiology: Study Design and Data Analysis by M. Woodward in Back Matter (1), Back Matter (2), and Back Matter (3)
- Group Sequential Methods (Chapman & Hall/CRC Interdisciplinary Statistics) by Christopher Jennison in Back Matter (1), and Back Matter (2)
- Drug Safety Assessment in Clinical Trials (Statistics: A Series of Textbooks and Monographs) by Gilbert in Front Matter, and Back Matter
- Statistics in the Pharmaceutical Industry (Chapman & Hall/CRC Biostatistics Series) by Buncher in Front Matter, and page 282
- Growth Curves (Statistics: A Series of Textbooks and Monographs) by Anant Kshirsagar in Front Matter
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