Lithium, the treatment of choice for mania since its usefulness was first reported, has been shown to have varied effects on multiple biological systems, including electrolyte flux and neurochemistry. Recent advances in cellular and molecular biology promise to provide clinicians with a better understanding of the etiology of bipolar disorder and new options for treatment. Bipolar Medications: Mechanisms of Action presents the treatment and prophylaxis of bipolar disorder. More than 40 investigators share research and insight into the neurobiological mechanisms that help to explain the powerful effects of new antibipolar drugs. This comprehensive text -Examines valproic acid, lamotrigine, inositol monophosphatase inhibitors, and protein kinase C inhibitors that have the potential to revolutionize clinical practice and provide new hypotheses on the etiology of bipolar disorder -Presents the current understanding of the cellular mechanisms of action of mood-stabilizing agents -Discusses the emergence of valproate as a powerful lithium alternative and examines the preliminary indications that lamotrigine will be an effective option -Examines the issue of withdrawal rebound, which can make lithium ineffective or even counterproductive, and reviews inositol monophosphatase inhibitors that mimic lithium action in patients -Compares lithium, carbamazepine, and valproate and their differential mechanisms, which could form the basis of a "rational polypharmacy" of manic depressive illness -Examines behavioral models important in the screening of new antibipolar compounds and the effects of antibipolar compounds on immediate early genes Complete with extensive references, tables, and figures, this text is essential reading for any clinician who treats patients with bipolar disorder. It thoroughly documents the latest in psychopharmacology, as well as projecting future advances in the treatment of bipolar disorder.
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Editorial Reviews
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...can be recommended strongly to researchers and practicing clinicians alike ... it contains important information that is highly relevant to both -- H. Christian Fibiger, Ph.D, Eli Lilly and Company, Indianapolis, Indiana
...represents an undertaking of massive scholarship covering a truly extraordinary range of scientific...The book is a monumental achievement -- Ross J. Baldessarini, M.D., Professor of Psychiatry-Neuroscience, Harvard Medical School, Belmont, Massachusetts
...represents an undertaking of massive scholarship covering a truly extraordinary range of scientific...The book is a monumental achievement -- Ross J. Baldessarini, M.D., Professor of Psychiatry-Neuroscience, Harvard Medical School, Belmont, Massachusetts
About the Author
Husseini K. Manji, M.D., F.R.C.P.C., is Director of the Laboratory of Molecular Pathophysiology in the Department of Psychiatry and Behavioral Neurosciences at Wayne State University School of Medicine in Detroit, Michigan. Charles L. Bowden, M.D., is the Nancy U. Karren Professor and Interim Chair of the Department of Psychiatry at the University of Texas Health Science Center at San Antonio, In San Antonio, Texas. Robert H. Belmaker, M.D., is Hoffer-Vickar Professor of Psychiatry at Beer Sheva Mental Health Center and on the Faculty of Health Sciences at the Ben Gurion University of the Negev in Beersheva, Israel.
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Front Cover | Front Flap | Table of Contents | First Pages | Index | Back Flap | Back Cover | Surprise Me!
Inside This Book
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Despite 50 years having elapsed since the initial report of its efficacy (Cade 1949), lithium remains a mainstay for the treatment of bipolar disorder (Post et al. 1998). Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
brain inositol levels, brain signal transduction systems, mouse cerebral cortex slices, chronic lithium treatment, phosphoinositide signal transduction system, dietary lithium, schizoaffective bipolar disorder, transduction disturbances, lithium inhibition, inositol depletion hypothesis, antibipolar drugs, lithium food, lithium administration alters, lithium pretreatment, chronic lithium administration, bicarbonate saline, inositol treatment, inositol monophosphatase, lithium exerts, lithium augments, brain cortex slices, phosphoinositide system, cerebrocortical slices, lithium plasma levels, antimanic effects Key Phrases - Capitalized Phrases (CAPs): (learn more)
Brain Res, Biol Psychiatry, Biol Chem, Arch Gen Psychiatry, Clin Psychiatry, New York, Proc Natl Acad Sci, Clin Psychopharmacol, Affect Disord, Pharmacol Exp Ther, American Psychiatric Association, Life Sci, Mol Pharmacol, Pharmacol Toxicol, Trends Pharmacol Sci, Psychiatry Res, Psychol Med, Psychopharmacol Bull, Eurj Pharmacol, Mol Psychiatry, Neurosci Lett, Academic Press, Biochem Pharmacol, Journal of Clinical Psychiatry, Oxford University Press New!
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Front Cover | Front Flap | Table of Contents | First Pages | Index | Back Flap | Back Cover | Surprise Me!
Despite 50 years having elapsed since the initial report of its efficacy (Cade 1949), lithium remains a mainstay for the treatment of bipolar disorder (Post et al. 1998). Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
brain inositol levels, brain signal transduction systems, mouse cerebral cortex slices, chronic lithium treatment, phosphoinositide signal transduction system, dietary lithium, schizoaffective bipolar disorder, transduction disturbances, lithium inhibition, inositol depletion hypothesis, antibipolar drugs, lithium food, lithium administration alters, lithium pretreatment, chronic lithium administration, bicarbonate saline, inositol treatment, inositol monophosphatase, lithium exerts, lithium augments, brain cortex slices, phosphoinositide system, cerebrocortical slices, lithium plasma levels, antimanic effects Key Phrases - Capitalized Phrases (CAPs): (learn more)
Brain Res, Biol Psychiatry, Biol Chem, Arch Gen Psychiatry, Clin Psychiatry, New York, Proc Natl Acad Sci, Clin Psychopharmacol, Affect Disord, Pharmacol Exp Ther, American Psychiatric Association, Life Sci, Mol Pharmacol, Pharmacol Toxicol, Trends Pharmacol Sci, Psychiatry Res, Psychol Med, Psychopharmacol Bull, Eurj Pharmacol, Mol Psychiatry, Neurosci Lett, Academic Press, Biochem Pharmacol, Journal of Clinical Psychiatry, Oxford University Press New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Front Flap | Table of Contents | First Pages | Index | Back Flap | Back Cover | Surprise Me!
Citations (learn more)
4
books
cite this book:
- Signal Transduction and Human Disease by Toren Finkel on page 440, and page 443
- Surviving Manic Depression: A Manual on Bipolar Disorder for Patients, Families, and Providers by E. Fuller Torrey M.D. in Back Matter
- Seminars in Clinical Psychopharmacology, 2nd Edition by David King on page 277
- Handbook of Bipolar Disorder: Diagnosis and Therapeutic Approaches (Medical Psychiatry Series) by Siegfried Kasper on page 150
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