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Bitter Nemesis: The Intimate History of Strychnine
 
 
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Bitter Nemesis: The Intimate History of Strychnine [Paperback]

John Buckingham (Author)
3.0 out of 5 stars  See all reviews (2 customer reviews)

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Book Description

July 16, 2007 1420053159 978-1420053159 1
Encouraged by the medicinal success of quinine, early 19th century scientists hoped strychnine, another plant alkaloid with remarkable properties, might also become a new weapon against disease. Physicians tried for over a century, despite growing evidence to the contrary, to treat everything from paralysis to constipation with it. But strychnine proved only to be disappointingly deadly-relegating its fate almost entirely to animal control, the dangerous adulteration of foods, and criminal exploits.

The NOTORIOUS and TRUE story of how a POISONOUS alkaloid...

Bitter Nemesis: The Intimate History of Strychnine presents a scholarly and compelling history of this fascinating chemical substance from its discovery to present times. A renowned editor for the Dictionary of Natural Products, Dr. John Buckingham fuses his eclectic interests into an extraordinary mix of original research spanning the realms of history, medicine, literature, chemistry, and forensics.

...Changed the course of HISTORY!

Uncovering details and logistics from the earliest experiments performed in an era when proper scientific trials for testing new drugs were still in their infancy, the author explores strychnine's trial-and-error contributions to scientific, medical, and forensic developments. He also investigates historical milestones and the perception of strychnine in popular culture-including criminal notoriety, accidental misuse, and new claims of strychnine's benefits that extend through to the present day.

Juxtaposing the real trials, mistrials, and persistent curiosity associated with one of history's most notorious pharmaceutical failures, Bitter Nemesis offers rare insight into the anarchic, yet inspired landscape, practices, and legacy of 19th century science.

Editorial Reviews

Review

"The book is well researched and thorough. Citations are endnotes to each chapter, and a bibliography and index are included at the end. This book is a cultural history of strychnine, not a natural history, or medical treatise. There is a strong bias to strychnine's place in British, French, and American culture, with surprisingly little information on its origins and use in India and Asia. I found the detailed accounts of murder trials, involving a cast of seemingly thousands, to be hard going, but I enjoyed the rare flashes of Buckingham's dark humor scattered throughout the text."
—Scott Zona, Fairchild Tropical Botanic Garden, in Economic Botany, 62(2), 2008, pp. 192-204

"Mixing science, history, and intriguing true accounts with his own touch of humor, Buckingham has created an enjoyable read for anyone with interest in scientific history."
Books to Note, Spring 2009, Vol. 27, No. 1

". . . Bitter Nemesis is the wonderful result of Buckingham’s passions and perspectives. Clearly, strychnine has come out on top again!" 
—Jeffrey I. Seeman, Department of Chemistry, University of Richmond, in Angewandte Chemie International Edition, 2008, Vol. 47

". . . well written and it would be highly entertaining light reading by chemists for their sheer pleasure."
—Joseph G. Cannon, Division of Medicinal Chemistry, College of Pharmacy, University of Iowa, in Journal of Medicinal Chemistry, 2008, Vol. 51, No. 12

About the Author

Consultant Editor, Dictionary of Natural Products, London

Product Details

  • Paperback: 320 pages
  • Publisher: CRC Press; 1 edition (July 16, 2007)
  • Language: English
  • ISBN-10: 1420053159
  • ISBN-13: 978-1420053159
  • Product Dimensions: 9 x 6 x 0.8 inches
  • Shipping Weight: 1 pounds (View shipping rates and policies)
  • Average Customer Review: 3.0 out of 5 stars  See all reviews (2 customer reviews)
  • Amazon Best Sellers Rank: #3,133,345 in Books (See Top 100 in Books)

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Customer Reviews

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2.0 out of 5 stars Almost no Chemistry, May 20, 2008
By 
Howard Mcpherson (Cleveland, Ohio United States) - See all my reviews
(REAL NAME)   
This review is from: Bitter Nemesis: The Intimate History of Strychnine (Paperback)
When I saw this book reviewed in Angew. Chem. Int. Eng. Ed. I thought it would be a great discussion of the long, difficult structure determination and the various total syntheses starting with the synthesis of Robert Burns Woodward. However, this book has almost nothing about the chemistry. A brief discussion of Sir Robert Robinson on structure determination and brief mention of the Woodward work is given without any chemical schemes. Page 227 does show 5 formulas that were proposed with structure "e" being the correct one proposed by Robinson, V. Prelog, and Woodward (all three were Nobel Prize winners in chemistry).
Very disappointing. Maybe someday someone will write a book about the chemistry.
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4.0 out of 5 stars Not for the average reader, December 19, 2007
By 
PJ Coldren (Saint Helen, MI, USA) - See all my reviews
(VINE VOICE)    (REAL NAME)   
This review is from: Bitter Nemesis: The Intimate History of Strychnine (Paperback)
BITTER NEMESIS is a medical and legal history of strychnine, beginning with its origins in India and tracing it through fairly modern times. There was, remarkable as it may seem now, a time when strychnine was viewed as a miracle drug, given on a regular basis as a tonic for women and children. Given the truly awful nature of a death from strychnine poisoning, it is difficult to understand why it fared so differently in the public perception than arsenic, for instance.

Quite a bit of BITTER NEMESIS is devoted to the legal arena. Several court cases are discussed very thoroughly. The acceptance by the courts of forensic evidence, it would seem, owes much to strychnine and its similarity to tetanus. The cases themselves are interesting, and Buckingham's analysis of them is quite thorough.

Buckingham is obviously an academic; there are footnotes for every chapter and an extensive bibliography. This does not mean his writing is dry and pedantic, just that sometimes there is a wealth of information that a reader may not find of interest. Depends, probably, on the expectations one brings to the book. If a person wishes to use BITTER NEMESIS as a resource when writing a mystery in which strychnine is used, the background is certainly there. There is enough information to write about a death by strychnine in enough detail for most readers.

While BITTER NEMESIS may not appeal to a universal audience, for those interested in such matters, it is an eminently readable book for anyone curious enough to track it down.
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Inside This Book (learn more)
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
pure strychnine, lignum colubrinum, false angostura, idiopathic tetanus, murder essay, nux vomica tree, strychnine hydrochloride, using strychnine, nux vomica seeds, strychnine poisoning, new alkaloid, colour test, tartar emetic, vegetable poisons, cumulative poison
Key Phrases - Capitalized Phrases (CAPs): (learn more)
William Palmer, Lloyd George, United States, Old Bailey, Talbot Arms, British Medical, Illustrated Times, Auguste Ballet, Elizabeth Mills, Saint Ignatius, Walter Palmer, Middle Ages, Apothecaries Hall, Christiana Edmunds, East India Company, Ethel Major, Linden House, Thomas Cream, Alfred Mason, Alfred Swaine Taylor, East Indies, First World War, George Griffiths, Helen Abercromby, John Gerard
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