This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research. Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques. A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNS · assesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans · presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters · examines the multidrug resistance protein P-glycoprotein as a natural transporter · analyzes current drug designs to known requirements for transport · looks at drug delivery systems for the brain · and much more! Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these disciplines.
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Editorial Reviews
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...a compact monograph that brings readers up to date on the blood-brain barrier and how scientists determine drug/chemical permeability across this functional partition....The contributions are a scholarly insight....provides good current information for scientists exploring the blood-brain barrier or working with chemical transport across its borders. Several exciting areas of research are spotlighted, introducing models to predict drug entry and distribution and using in vitro models of the barrier to predict chemical transport....an invaluable resource.
- Veterinary Human Toxicology, 2000
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First Sentence:
Among the factors that influence uptake and distribution of a drug into a tissue or organ outside the central nervous system (CNS) are blood flow, binding to proteins in blood plasma, clearance from blood, and metabolism. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
porcine brain capillary endothelial cells, simvastatin acid, hydrogen bond descriptors, brain uptake index, plexus epithelial cells, cationized albumin, choroid plexus tissue, brain delivery, chimeric peptides, brain microvessel endothelial cells, brain endothelial cells, peptide drug delivery, hydrogen bond acidity, brain extracellular fluid, coated nanoparticles, butyl cyanoacrylate, rat tail collagen, brain interstitial fluid, hydrogen bond basicity, cerebral endothelial cells, intracerebral microdialysis, endothelial cell monolayers, brain penetration, drug transport, inactive enantiomer Key Phrases - Capitalized Phrases (CAPs): (learn more)
Pharmacol Exp Ther, Brain Res, Proc Natl Acad Sci, Pharm Res, New York, Biol Chem, Clin Invest, Pharm Sci, Biochem Pharmacol, Med Chem, Cancer Res, Adv Drug Delivery Rev, Life Sci, Biochem Biophys Res Commun, Cell Biol, Drug Metab Dispos, Ann Neurol, Neurosci Lett, Pharm Pharmacol, Plenum Press, Raven Press, Acta Physiol Scand, Cell Physiol, Cereb Blood Flow Metab, Marcel Dekker New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Among the factors that influence uptake and distribution of a drug into a tissue or organ outside the central nervous system (CNS) are blood flow, binding to proteins in blood plasma, clearance from blood, and metabolism. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
porcine brain capillary endothelial cells, simvastatin acid, hydrogen bond descriptors, brain uptake index, plexus epithelial cells, cationized albumin, choroid plexus tissue, brain delivery, chimeric peptides, brain microvessel endothelial cells, brain endothelial cells, peptide drug delivery, hydrogen bond acidity, brain extracellular fluid, coated nanoparticles, butyl cyanoacrylate, rat tail collagen, brain interstitial fluid, hydrogen bond basicity, cerebral endothelial cells, intracerebral microdialysis, endothelial cell monolayers, brain penetration, drug transport, inactive enantiomer Key Phrases - Capitalized Phrases (CAPs): (learn more)
Pharmacol Exp Ther, Brain Res, Proc Natl Acad Sci, Pharm Res, New York, Biol Chem, Clin Invest, Pharm Sci, Biochem Pharmacol, Med Chem, Cancer Res, Adv Drug Delivery Rev, Life Sci, Biochem Biophys Res Commun, Cell Biol, Drug Metab Dispos, Ann Neurol, Neurosci Lett, Pharm Pharmacol, Plenum Press, Raven Press, Acta Physiol Scand, Cell Physiol, Cereb Blood Flow Metab, Marcel Dekker New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 13
books:
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- Peptide Drug Delivery to the Brain (Order Code 2266) by William M. Pardridge on 4 pages
- Lipophilicity in Drug Action and Toxicology by Vladimir Pliska on page 31
- Quantitative Functional Brain Imaging with Positron Emission Tomography by Richard E. Carson on page 242
- Polymeric Nanoparticles & Microspheres by Pierre Guiot on page 223
- Florence Nightingale: Reputation and Power by F. B. Smith in Front Matter
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