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Blood Work: A Tale of Medicine and Murder in the Scientific Revolution [Hardcover]

Holly Tucker
4.3 out of 5 stars  See all reviews (29 customer reviews)


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Book Description

March 21, 2011
"A fast-paced and fascinating ride through a dark and devious period in science, Blood Work is a witty, insightful, and skillfully written book that sheds light on the mysterious story of blood transfusion." --Wendy Moore, author of The Knife Man

On a cold day in 1667, a renegade physician named Jean Denis transfused calf's blood into one of Paris's most notorious madmen. In doing so, Denis angered not only the elite scientists who had hoped to perform the first animal-to-human transfusions themselves, but also a host of powerful conservatives who believed that the doctor was toying with forces of nature that he did not understand. Just days after the experiment, the madman was dead, and Denis was framed for murder.

A riveting account of the first blood transfusion experiments in 17th-century Paris and London, Blood Work gives us a vivid glimpse of a particularly fraught period in history--a time of fire and plague, empire building and international distrust, when monsters were believed to inhabit the seas and the boundary between science and superstition was still in flux. Amid this atmosphere of uncertainty, transfusionists like Denis became embroiled in the hottest cultural debates and fiercest political rivalries of their day. As historian Holly Tucker reveals, transfusion's detractors would stop at nothing--not even murdering Denis's patient--to outlaw a practice that might jeopardize human souls, pave the way for monstrous hybrid creatures, or even provoke divine retribution.

Taking us from the highest ranks of society to the lowest, from dissection rooms in palaces to the filth-clogged streets of Paris, Blood Work sheds light on an era that wrestled with the same questions about morality and experimentation that haunt medical science to this day.


Editorial Reviews

From Publishers Weekly

Tucker, associate professor in Vanderbilt University's Center for Medicine, Health and Society, does a marvelous job of chronicling the 17th-century controversy pitting science against religion and shows how much of the language used then against the new technique of blood transfusion mirrors language used today against stem cell research and cloning. In 1667, building on work done in England, Jean-Baptiste Denis, a self-promoting young Frenchman, transfused lamb's blood into a human. His work angered many, including those who believed that the soul was housed in the blood and transfusion was blasphemous; others who clung to bloodletting as a treatment rather than blood transfusions; and those protecting their own scientific reputations from an unknown upstart. When Denis's second transfused patient died suddenly, Denis was accused of murder. Exploring the charge, Tucker unearths compelling evidence that the patient was murdered—by a cabal attempting to discredit Denis. The affair halted all experiments in blood transfusion for 150 years. Tucker's sleuthing adds drama to an utterly compelling picture of Europe at the moment when modern science was being shaped. B&w illus. (Mar.)
(c) Copyright PWxyz, LLC. All rights reserved.

Review

Holly Tucker does an incredible job of bringing the history of blood transfusion to life with harrowing immediacy, spinning a tale of blood, ambition, and murder so gripping that it reads with novelistic intensity. She also reminds us that science itself has a history, that the discipline which we trust to explain our world can also be bound up in the prejudices and assumptions of our own time. Anyone with a taste for historical intrigue will devour Blood Work, just as I did. (Katherine Howe, New York Times bestselling author of The Physick Book of Deliverance Dane)

Product Details

  • Hardcover: 304 pages
  • Publisher: W. W. Norton & Company; 1 edition (March 21, 2011)
  • Language: English
  • ISBN-10: 0393070557
  • ISBN-13: 978-0393070552
  • Product Dimensions: 5.9 x 1.1 x 8.7 inches
  • Shipping Weight: 14.4 ounces
  • Average Customer Review: 4.3 out of 5 stars  See all reviews (29 customer reviews)
  • Amazon Best Sellers Rank: #512,638 in Books (See Top 100 in Books)

More About the Author

Holly Tucker is Associate Professor at Vanderbilt University, where she holds appointments in the Center for Medicine, Health & Society and the Department of French & Italian. Holly teaches courses on the history of medicine as well as courses on French history and culture.

Her writing has appeared in the New Scientist, the Wall Street Journal, the San Francisco Chronicle, Christian Science Journal, among others. Holly is also the author of Blood Work: A Tale of Medicine & Murder in the Scientific Revolution (Norton, March 2011), and edits the general history website Wonders & Marvels.

Join Holly on her Facebook author page (http://www.facebook.com/hollytucker) or on Twitter (http://www.twitter.com/history_geek).

Holly's Upcoming Events:

Research Triangle Park, NC
-January 13-15, 2011 - Science Online 2011

Nashville
-March 2, 2011 - Thinking Out of the Lunch Box series, Nashville Public Library (Main)

New York (March)
-March 23, 2011 - CUNY Graduate School of Journalism
-March 23, 2011 - New York Academy of Medicine

Chicago
-March 30, 2011 - University of Illinois at Chicago
-March 30, 2011 - Newberry Library (Chicago)

Madison
-March 31, 2011 - Authors@HSLC (Madison)
-March 31, 2011 - Department of French & Italian (Madison-TBD)
-April 1, 2011 - History of Science Brownbag (Madison)

Chicago
-April 3, 2011 - International Museum of Surgical Science

Knoxville, TN
-April 8, 2011 - University of Tennessee-Knoxville

Boston/Cambridge
-April 14, 2011 - Harvard University

New York (April)
-April 29, 2011, 8:00pm - Observatory (New York)
-April 29-May 1, 2011 - American Society of Journalists and Authors (New York)

College Park, MD
-May 6-7, 2011 - Blood Work conference, University of Maryland

Baltimore
-May 12, 2011 - Berman Institute for Bioethics/Institute for the History of Medicine (Johns Hopkins, Baltimore)

Richmond, VA
-May 13, 2011 - Book signing, Fountain Bookstore

Nashville, TN
-October 14-16, 2011 - 2011 Southern Festival of Books

Boston/Cambridge
-Date TBA: Harvard University Renaissance Seminar

Salt Lake City
-Date TBA: Division of Medical Ethics and Humanities (University of Utah)

Customer Reviews

Most Helpful Customer Reviews
20 of 22 people found the following review helpful
5.0 out of 5 stars A steampunky mix of science, history, and politics February 26, 2011
Format:Hardcover
Who'd have guessed that some of the earliest experiments in therapeutic blood transfusion date to the seventeenth century, or that they were performed not between humans but from animals to humans--or that this actually seemed to work?

These are the bare facts of the story Holly Tucker tells in Blood Work, a novelistic mix of history, science, and the politics of Enlightenment-era Europe. Tucker describes how some of the founding Fellows of Britain's Royal Society began transfusion experiments, sparking a scientific race with rivals in France. And then the race was abandoned almost as quickly as it began, when an ambitious French physician's patient died under mysterious circumstances.

Tucker builds her tale from primary documents and illuminates it with beautiful period illustrations. Blood Work is not a long book--I finished most of it on a cross-country flight--but it's dense with detail. It's entertaining history of science, but it also has surprising resonance for today's debates over stem cell and genetic engineering technologies. If you like history, or science--or if you're a fan Neal Stephenson's Quicksilver and its sequels, you should check out Blood Work.
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8 of 8 people found the following review helpful
By GJ GBUR
Format:Hardcover
Blood Work tells the true story of the first animal-to-human blood transfusions, performed in the 1660s in England and Europe. These culminated in 1667 in Paris with a series of experiments performed by the rogue physician Jean-Baptiste Denis; the subject of the experiments was an infamous madman who was plucked from the streets against his will. Though the transfusions initially seemed successful, within days the madman had died, and the ensuing political fallout resulted in the suspension of all such studies for some 200 years. Most surprising, at the heart of the story is a conspiracy -- and Denis' opponents had no scruples against committing murder for the "greater good".

The book is delightfully written and painstakingly researched. Professor Tucker does an excellent job making the world of 17th century England and France come alive, and pulls back the curtain on the inner workings of the machinations of the elite politicians, scientists and nobles of the era. There were strong religious and scientific concerns about the safety of transfusions, and these concerns rather ironically mirror the modern fears about "human-animal hybrids" created by genetic engineering. Denis ended up bucking the medical establishment (some of whose members were planning their own experiments) and made powerful enemies in the process; his stubbornness would quickly catch up with him.

The earlier chapters of Blood Work will possibly be a bit slow-going to some readers. There is a lot of history behind the critical events of the book, primarily the medical studies that preceded said events. This background material is essential to the narrative, but is not quite as compelling as the latter parts of the book.

Once the story gets going, however, it is practically impossible to stop reading. Events rapidly gain momentum, and history rushes towards a dark finale that comes to seem almost inevitable. As I said, though, there is a dark secret behind the publicly-known story, and Professor Tucker manages to extract that secret from the historical records. The revelations those records contain are quite amazing, so much so that it is hard to believe that the story is not fictional! When the full scope of the events, and their consequences for medical progress are grasped, the history in fact becomes a tragedy.

There is one other caveat worth mentioning. The story of early blood transfusion is also the story of animal experimentation, centuries before anyone seriously considered the feelings of animals -- and long before anesthesia. The description of experiments on animals (again, essential to understanding the story) is not for the squeamish.

That being said, by the end of the book I was completely transfixed by the tale that was being told. Holly Tucker's Blood Work shares an amazing story with great dexterity, and is well-worth reading.
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11 of 12 people found the following review helpful
5.0 out of 5 stars Thoroughly enjoyable true crime mystery March 1, 2011
Format:Hardcover
I've been hearing so much early press on this book--so decided to give it a shot. It's amazing to me how well Tucker weaves fascinating details about the first blood transfusion experiments into a very readable "who done it" mystery. It's a true story that reads like a mystery novel--think Eric Larson's Devil in the White City. Loved Blood Work and would recommend it!
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Most Recent Customer Reviews
4.0 out of 5 stars Critical Acclaim for Blood Work
Holly Tucker's BLOOD WORK is an accurate, captivating representation of what was an otherwise poorly documented medical breakthrough--a must-read for any person interested in the... Read more
Published 3 months ago by Russell J. Pepe
2.0 out of 5 stars Tainted History
Blood Work: A Tale of Medicine and Murder could have been a very interesting and historically significant publication had it not been tainted by Tucker's support for embryonic... Read more
Published 3 months ago by Maryann Bowne
2.0 out of 5 stars Well researched
I keep picking it up and trying to finish but am only halfway. Another purchase based on a Terry Gross- Fresh Air interview where the book failed to be as interesting as the... Read more
Published 5 months ago by juliesalle
5.0 out of 5 stars History is stranger than fiction!
I read a review for the book when we were in Nashville for my husband's stem cell transplant. I found the history and the people interesting and the story both interesting and... Read more
Published 8 months ago by Sue Opp
3.0 out of 5 stars dracula was a frenchman
very interesting tale of early medical practices (now I know why its not "medical perfects") can be somewhat chilling and slows down at times but I think important slice of... Read more
Published 8 months ago by filmart
3.0 out of 5 stars Blood Work by Holly Tucker
When I first saw Holly Tucker on C-Span talking about her book Blood Work, and the history of blood transfusion, I became very excited to read it. Read more
Published 10 months ago by Sherrill Kiser
5.0 out of 5 stars Utterly fascinating
This book was enthralling! Being a life science teacher I know a lot about the workings of the blood, but I knew absolutely nothing about the history of the discovery of the... Read more
Published 13 months ago by derrick
5.0 out of 5 stars Blood Works
Great book on how the first blood transfusions were performed. Holly Tucker is a wonderful story teller. Worth the read!!
Published 16 months ago by Agustin Pabon Jr.
3.0 out of 5 stars A potent brew
This is a rather hard book to categorize, much less describe in any kind of facile way. Suffice it to say it's not going to be everyone's cup of literary poison. Read more
Published 18 months ago by T. Wayne
5.0 out of 5 stars Excellent review of the history of blood transfusion
Just finished reading this excellent book on the history of blood transfusions during the 17th century. Read more
Published 19 months ago by Ajeet Sharma
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