In this innovative and challenging book, William Pardridge, a world leader in the study of the blood-brain barrier and its clinical implications, argues that brain drug development has been restricted by the failure of adequate brain drug targeting. This is an increasingly urgent problem as developments in genomics lead to new generations of therapeutic macromolecules. The author reviews the field of neurotherapeutics from the point of view of drug targeting. He surveys the scientific and clinical basis of drug delivery across biological membranes, including topics such as genetically engineered trojan horses for drug targeting, antisense neurotherapeutics, and gene therapy of brain disorders. At a time when there are few significant new drug treatments in prospect for common neurological diseases, this authoritative review will encourage a wide range of clinicians and neuroscientists to reexamine the development and use of drugs in treating disorders of the central nervous system.
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Book Description
Editorial Reviews
Review
"Just as the author does an excellent job arguing for the need for more work in this area, he also goes in depth describing all the inherent pitfalls as well as possible solution necessary to develop large-molecule pharmaceuticals for brain disease." The Annals of Pharmacotherapy April 2002
"...a book that will become a standard on drug targeting to the brain...a must for everybody who works in the field of brain drug delivery in academia as well as in the pharmaceutical industry." Journal of Clinical Pathology
"This is an excellent book, to be expected from a major researcher in the field. The lucid text is illuminated by an eclectic mix of diagrams and plates that will have a broad appeal to a wide audience within the biomedical, pharmaceutical and imaging sciences." British Journal of Neurosurgery
"...a book that will become a standard on drug targeting to the brain...a must for everybody who works in the field of brain drug delivery in academia as well as in the pharmaceutical industry." Journal of Clinical Pathology
"This is an excellent book, to be expected from a major researcher in the field. The lucid text is illuminated by an eclectic mix of diagrams and plates that will have a broad appeal to a wide audience within the biomedical, pharmaceutical and imaging sciences." British Journal of Neurosurgery
Book Description
Brain drug development has been restricted by the failure of adequate brain drug targeting, an increasingly urgent problem as developments in genomics lead to new generations of therapeutic macromolecules. This challenging book reviews the field of neurotherapeutics from the point of view of drug targeting, surveying the scientific and clinical basis of drug delivery across biological membranes. It will encourage a wide range of clinicians and neuroscientist s to reexamine the development and use of drugs in treating disorders of the central nervous system.
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Inside This Book
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First Sentence:
The brain of all vertebrates is protected from substances in the blood by the blood-brain barrier (BBB). Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
brain drug targeting, intracarotid arterial infusion, chimeric peptide technology, isolated rat brain capillaries, brain capillary preparation, large molecule pharmaceuticals, daunomycin encapsulated, following cationization, lipid mediation, organic anion transporting polypeptide type, pegylated immunoliposomes, peptidomimetic monoclonal antibodies, brain drug development, rat brain microvasculature, pegylation technology, protein pegylation, antisense radiopharmaceuticals, biotinylated drug, isolated human brain capillaries, adenosine carrier, peptide radiopharmaceuticals, internal carotid artery perfusion, neuropeptide transport, isolated bovine brain capillaries, cationized human serum albumin Key Phrases - Capitalized Phrases (CAPs): (learn more)
National Academy of Sciences, Elsevier Science, New World, Old World, American Chemical Society, United States, Brain Res, Natl Acad, John Wiley, The Alfred Benzon Foundation, These Northern New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
The brain of all vertebrates is protected from substances in the blood by the blood-brain barrier (BBB). Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
brain drug targeting, intracarotid arterial infusion, chimeric peptide technology, isolated rat brain capillaries, brain capillary preparation, large molecule pharmaceuticals, daunomycin encapsulated, following cationization, lipid mediation, organic anion transporting polypeptide type, pegylated immunoliposomes, peptidomimetic monoclonal antibodies, brain drug development, rat brain microvasculature, pegylation technology, protein pegylation, antisense radiopharmaceuticals, biotinylated drug, isolated human brain capillaries, adenosine carrier, peptide radiopharmaceuticals, internal carotid artery perfusion, neuropeptide transport, isolated bovine brain capillaries, cationized human serum albumin Key Phrases - Capitalized Phrases (CAPs): (learn more)
National Academy of Sciences, Elsevier Science, New World, Old World, American Chemical Society, United States, Brain Res, Natl Acad, John Wiley, The Alfred Benzon Foundation, These Northern New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 9
books:
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2
books
cite this book:
- Nutrition and the Brain, Vol. 6: Physiological and Behavioral Effects of Food Constituents by Richard J. Wurtman in Back Matter (1), and Back Matter (2)
- Advances in Inflammation Research by Gerald Weissmann in Back Matter
- Clinical Applications of Neurotrophic Factors by Stuart C., M.D. Apfel in Back Matter
- The Endocrine System: Systems of the Body Series, 1e by Joy P. Hinson BSc PhD DSc FHEA in Back Matter
- Peptide Drug Delivery to the Brain (Order Code 2266) by William M. Pardridge in Back Matter
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