The author declares that the basic aim of this book is to impart the fundamentals of the way in which he begins with laboratory results and ends up with numbers representing genetic risks. Intended as a practical guide for both clinical and research geneticists, it explains how to calculate an individual's genetic risk based on information from genetic testing and family pedigrees. The author starts with the general theory of estimating genetic risks and progresses through familial and isolated cases, both simple and complex. Worked examples are provided throughout the text. The disorders are selected to be widely applicable or adaptable as needed.
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Editorial Reviews
Review
'From reviews of the first edition:' "To use a computer package intelligently and safely, you need to have in reserve the ability to do the calculation by hand, at least approximately, so as to appreciate which factors contribute to the risk. Bridge's book is very thorough. Every combination of pedigree structure and marker data is discussed, with numerous tables showing the result of systematically varying one or more parameter."--'Journal of Medical Genetics' "A useful reference book."--'American Journal of Human Genetics'
--This text refers to an out of print or unavailable edition of this title.
Review
"To use a computer package intelligently and safely, you need to have in reserve the ability to do the calculation by hand, at least approximately, so as to appreciate which factors contribute to the risk. Bridge's book is very thorough. Every combination of pedigree structure and marker data is discussed, with numerous tables showing the result of systematically varying one or more parameter." -- Journal of Medical Genetics, reviewing a previous edition or volume
"A useful reference book." -- American Journal of Human Genetics, reviewing a previous edition or volume
--This text refers to an out of print or unavailable edition of this title.
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