Carcinogens, like chemicals with other toxic hazards, often produce adverse effects only in specific organs or tissues. The factors determining whether a chemical induces cancer in an organ range from simple toxicokinetics to complex phenomena such as expression or lack of expression of specific genes.; This volume examines the site-specific factors involved in carcinogenesis in the liver, gastrointestinal tract, kidney, urinary bladder, respiratory system, skin, nervous system, male reproductive system, and haematopoietic system. For each organ, the book provides current information on chemicals causally associated with cancer, mechanisms of carcinogenesis, and pathophysiology of induced tumours, and identifies the processes determining susceptibility in the organ. Full consideration is also given to the procedures used in animal carcinogenesis studies and the extrapolation of the results to humans.
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First Sentence:
For a book such as this, devoted generally to carcinogenesis in specific organ systems of animals, it may represent an anomaly to recall that the carcinogenic effects of a sizable number of environmental or industrial materials were first noted in humans. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
testis cancer risk, tubular cell tumors, prostatic cell proliferation, renal mesenchymal tumors, testicular tumorigenicity, prenatal estrogen exposure, intermediate epithelium, cell tumor formation, potentiated hyperplasia, renal epithelial tumors, urinary bladder carcinogens, gastric carcinogenesis induced, testicular tumorigenesis, rat stomach mucosa, following transplacental exposure, renal tumorigenesis, testicular cancer risk, nasal carcinogenesis, positive association between risk, dorsolateral prostate, persistent hyperplasia, perinatal carcinogenesis, hematopoietic tumors, cell tumorigenesis, moderate hyperplasia Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cancer Res, New York, Natl Cancer Inst, Environ Health Perspect, United States, Proc Natl Acad Sci, Nail Cancer Inst, Raven Press, National Cancer Institute, Cancer Lett, Toxicol Appl Pharmacol, Academic Press, National Toxicology Program, Biol Chem, Boca Raton, Proc Nail Acad Sci, Crit Rev Toxicol, Ind Med, Fundam Appl Toxicol, Plenum Press, Research Triangle Park, Work Environ Health, Human Lung, Invest Dermatol, Scientific Publications New!
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Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
For a book such as this, devoted generally to carcinogenesis in specific organ systems of animals, it may represent an anomaly to recall that the carcinogenic effects of a sizable number of environmental or industrial materials were first noted in humans. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
testis cancer risk, tubular cell tumors, prostatic cell proliferation, renal mesenchymal tumors, testicular tumorigenicity, prenatal estrogen exposure, intermediate epithelium, cell tumor formation, potentiated hyperplasia, renal epithelial tumors, urinary bladder carcinogens, gastric carcinogenesis induced, testicular tumorigenesis, rat stomach mucosa, following transplacental exposure, renal tumorigenesis, testicular cancer risk, nasal carcinogenesis, positive association between risk, dorsolateral prostate, persistent hyperplasia, perinatal carcinogenesis, hematopoietic tumors, cell tumorigenesis, moderate hyperplasia Key Phrases - Capitalized Phrases (CAPs): (learn more)
Cancer Res, New York, Natl Cancer Inst, Environ Health Perspect, United States, Proc Natl Acad Sci, Nail Cancer Inst, Raven Press, National Cancer Institute, Cancer Lett, Toxicol Appl Pharmacol, Academic Press, National Toxicology Program, Biol Chem, Boca Raton, Proc Nail Acad Sci, Crit Rev Toxicol, Ind Med, Fundam Appl Toxicol, Plenum Press, Research Triangle Park, Work Environ Health, Human Lung, Invest Dermatol, Scientific Publications New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 5
books:
- Diet and Health: Implications for Reducing Chronic Disease Risk by National Research Council (U. S.) on page 394
- Immunotoxicology And Immunopharmacology (Exploring God's World with Michael and Caroline Carroll) by Jack H Dean in Front Matter
- Toxicology Of The Eye, Ear, And Other Special Senses (Target Organ Toxicology Series) by A. Wallace Hayes in Front Matter
- Toxicology of the Blood and Bone Marrow (Target Organ Toxicology Series) by Richard D. Irons in Front Matter
- Toxicology of the Lung by Donald E. Gardner in Front Matter
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