This study is devoted to CD23, the 45-kilodalton glycoprotein which is also referred to as the low affinity IgE receptor. International research groups describe multi-functional aspects of soluble CD23 with respect to lymphocyte physiology and discuss its likely role in vivo as well as its signficance in antigen presentation. Following an historical overview, a molecular description of CD23 in both mouse and man is presented. The majority of contributions then concentrate on the function of this molecule where new development reveals its pleiotropic role in immune and haemopoietic regulation. Some papers focus on the potential role of CD23 in regulating IgE synthesis, while others consider its participation in non-IgE-related functions.
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