Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.
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Inside This Book
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First Sentence:
Genetic studies in mice have made a major contribution to our current understanding of mammalian biology. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
atupic dermatitis, duced arthritis, involucrin promoter, epicutaneous sensitization, skin phenotype, microbial exposure, contact hypersensitivity reactions, experimental asthma, targeted locus, helper cell type, sensitized skin, epidermal hyperproliferation, chronic intestinal inflammation, experimental colitis, contact sensitizers, lesional skin, dermal infiltrate, hygiene hypothesis, inflammatory skin disease, atopic dermatitis, leukocyte rolling, selection marker, allergic dermatitis, adjuvant arthritis, skin inflammation Key Phrases - Capitalized Phrases (CAPs): (learn more)
Exp Med, Clin Invest, Invest Dermatol, Nat Med, Invest Dcrmatol, Journal of Immunology, Nat Genet, Proc Nall Acad Sci, Arch Dermatol, Arthritis Rheum, Nucleic Acids Res, Models of Experimental Asthma, Nat Immunol, Respir Cell Mol Biol, Clin Exp Allergy, Mol Med, Allergy Clin Immunol, Hum Genet, Immunol Rev, Immunol Today, Modelling Gene-Environment Interactions, Mol Cell Biol, Proc Natl Acad Sci, Skin Pharmacol, Thl T-cell New!
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Front Cover | Table of Contents | First Pages | Back Cover | Surprise Me!
Genetic studies in mice have made a major contribution to our current understanding of mammalian biology. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
atupic dermatitis, duced arthritis, involucrin promoter, epicutaneous sensitization, skin phenotype, microbial exposure, contact hypersensitivity reactions, experimental asthma, targeted locus, helper cell type, sensitized skin, epidermal hyperproliferation, chronic intestinal inflammation, experimental colitis, contact sensitizers, lesional skin, dermal infiltrate, hygiene hypothesis, inflammatory skin disease, atopic dermatitis, leukocyte rolling, selection marker, allergic dermatitis, adjuvant arthritis, skin inflammation Key Phrases - Capitalized Phrases (CAPs): (learn more)
Exp Med, Clin Invest, Invest Dermatol, Nat Med, Invest Dcrmatol, Journal of Immunology, Nat Genet, Proc Nall Acad Sci, Arch Dermatol, Arthritis Rheum, Nucleic Acids Res, Models of Experimental Asthma, Nat Immunol, Respir Cell Mol Biol, Clin Exp Allergy, Mol Med, Allergy Clin Immunol, Hum Genet, Immunol Rev, Immunol Today, Modelling Gene-Environment Interactions, Mol Cell Biol, Proc Natl Acad Sci, Skin Pharmacol, Thl T-cell New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Back Cover | Surprise Me!
Citations (learn more)
This book cites 32
books:
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- BIOS Instant Notes in Molecular Biology by Phil Turner in Back Matter
- Cellular Therapy (Ernst Schering Foundation Symposium Proceedings) by H. Wekerle in Back Matter
- Stem Cell Transplantation and Tissue Engineering (Ernst Schering Foundation Symposium Proceedings) by A. Haverich in Back Matter
- Pharmacokinetic Challenges in Drug Discovery by O. Pelkonen in Back Matter
- New Concepts in Pathology and Treatment of Autoimmune Disorders (Ernst Schering Foundation Symposium Proceedings / Schering Foundation Symposium Proceedings Supplements) by C. Pozzilli in Back Matter
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