Cells, Aging, and Human Disease [Hardcover]

Michael B. Fossel M.D. (Author)

Book Description

Publication Date: June 10, 2004 | ISBN-10: 0195140354 | ISBN-13: 978-0195140354 | Edition: 1

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease.

Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy.

The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.

Editorial Reviews

Review

"Readers interested in an account that places cellular senescence at the epicenter of human aging and assembles as much evidence as possible to suppport that view will find a great deal to satisfy them in Cells, Aging, and Human Disease. --Science

About the Author

Michael B. Fossel is at Michigan State University.

Product Details

• Hardcover: 504 pages
• Publisher: Oxford University Press, USA; 1 edition (June 10, 2004)
• Language: English
• ISBN-10: 0195140354
• ISBN-13: 978-0195140354
• Product Dimensions: 9.2 x 6.1 x 1.1 inches
• Shipping Weight: 1.8 pounds (View shipping rates and policies)
• Amazon Best Sellers Rank: #896,095 in Books (See Top 100 in Books)

More About the Author

Born in 1950 in Greenwich, Connecticut in the United States, Michael Fossel grew up New York, and lived in London, Palo Alto, San Francisco, Portland, and Denver. He graduated cum laude from Phillips Exeter Academy, received a joint BA (cum laude) and MA in psychology in four years from Wesleyan University in Connecticut, and, after completing a PhD in neurobiology at Stanford University in 1978, went on to finish his MD at Stanford Medical School in two and a half years. He was awarded a National Science Foundation Fellowship and taught at Stanford University, where he began studying aging, emphasizing premature aging syndromes. Dr. Fossel is a Clinical Professor of Medicine at Michigan State University.
He is a Fellow of the American College of Emergency Physicians, and a member of numerous scientific organizations including the American Association for the Advancement of Science, the American Aging Association (he was their executive director and serves on their board of directors), the American Gerontological Society, the American Society on Aging, and the American Geriatrics Society, among others.
He has lectured at the National Institute for Health, the Smithsonian Institute, and at universities and institutes internationally. He was founding editor of the Journal of Anti-Aging Medicine. His numerous articles on aging and ethics in the Journal of the American Medical Association, In Vivo, and other academic journals have sparked discussion and frequent calls for him to speak worldwide to both medical groups and the general public. He is frequently interviewed regarding aging by major media in the US and worldwide.
In 1996, Dr. Fossel published Reversing Human Aging, discussing the cellular causes of aging, how the process can be altered, and the social and financial implications of reversing human aging. The book was reviewed favorably in national full page newspaper articles and in Scientific American. It has now been published in six languages. He has appeared on Good Morning America, ABC 20/20, NBC Extra, Fox Network, CNN, the BBC, the Discovery Channel, and regularly on NPR.
His textbook, Cells, Aging, and Human Disease, was published in 2004 by Oxford University Press. An extensive look at the field, with well over four thousand up-to-date references, it reviews the entire fields of telomere biology and cell senescence as they apply to human clinical diseases and aging. It includes in depth discussions of Alzheimer's disease, the progerias, atherosclerosis, osteoporosis, immune senescence, skin aging, and cancer, as well as the potential for fundamentally new therapies for these diseases.