This work examines recent advances in excitotoxic mechanisms, calcium and cell death, acidosis and cell death, inflammation and the immune system, trophic mechanisms and protein synthesis, and changes in gene expression. Dicussion includes glutamate and neurodegeneration in vitro; the involvement of glutamate actions on astrocytes; the mechanisms of calcium-related cell death; the pathophysiology of acidosis-related brain damage; acidosis and cell death in vitro and the protective effect of acidosis in vitro; inflammatory reactions at the blood-endothelial cell interface; free radical formation and microvascular dysfunction; the role of trophic factors in the post-ischaemic brain and the signal transduction mechanism regulating trophic processes in the post-ischaemic brain; immediate early genes and their role in neuronal death; and the heat shock in the post-ischaemic brain.
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Cerebral Ischemia: Mechanisms in Pathology,
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This review is from: Cellular & Molecular Mechanisms of Ischemic Brain Damage (Hardcover)
This is a fantastic book ca: 1994, printed 1996, which is still relevant for scientists in the year 2005. The book covers the minute details of cerebral ischemia mechanisms discussing glutamate excitotoxicity, calcium, IEG, c-fos, c-jun, hypothermia, LTP, LTD, spreading depression, steroids, free radicals and scavengers, ZN-SOD, NO and NO Synthase, and many other topics. There are over 50 chapters, making this a comprehensive coverage. The material is dated so that one must not rely on this book for everything. Wolfgang Walz wrote a more recent volume entitled Cerebral Ischemia by Humana which is worth looking at. Bo Siesjo and T. Wieloch are the editors so you know it is going to be good with excellent commentaries at the end of each chapter & section. Bo apparently moved from Lund so that contacting him could be difficult.
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