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Cellular and Molecular Toxicology and In Vitro Toxicology
 
 
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Cellular and Molecular Toxicology and In Vitro Toxicology [Paperback]

Daniel Acosta Jr. (Author)

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Book Description

0849344212 978-0849344213 August 22, 1990 1
This work concentrates on cellular and molecular toxicity of selected well-known drugs or chemicals on the cardiovascular system. The primary objective is to provide a better understanding of the mechanisms by which xenobiotics are toxic to mammalian tissues and cells. The use of in vitro cellular and tissue systems provides attractive experimental models to assess toxic manifestations of xenobiotics. This work addresses the most recent findings on the cellular and molecular mechanisms of toxicity of several important cardiotoxic agents: doxorubicin, ethanol, cocaine, and the catecholamines. It presents an overview of vascular toxins and their biochemical effects. Included is a summary of in vitro cardiovascular techniques for assessing toxicity of xenobiotics. This publication is important for those in toxicology, tissue culture, pharmacology, in vitro toxicology, developmental biology and related areas.

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Inside This Book (learn more)
First Sentence:
Cardiac toxins have been studied for many years, and much is known about how chemicals injure the heart. Read the first page
Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
contraction band lesions, paradiscal lesions, allylamine cardiovascular toxicity, coagulative myocytolysis, cocaine cardiotoxicity, muscle cell injury, isolated cardiac preparations, vascular toxins, cultured myocardial cells, chronic cardiotoxicity, anthracycline cardiotoxicity, membrane permeability alterations, atria contracting, anthracycline therapy, doxorubicin cardiotoxicity, free radical hypothesis, chronic ethanol ingestion, cultured vascular smooth muscle cells, adriamycin cardiotoxicity, contraction band necrosis, alcoholic cardiomyopathy, cardiac necrosis, myofibrillar degeneration, cardiotoxic effects, myocardial necrosis
Key Phrases - Capitalized Phrases (CAPs): (learn more)
New York, Cancer Res, University Park Press, Cell Cardiol, Boca Raton, Cancer Treat, Mol Cell, Cancer Chemother Pharmacol, Del Tacca, Life Sci, Plenum Press, Res Commun, Acta Med, Alcohol Drug Res, Biol Chem, Metabolite Effects, Alcohol Clin, Biol Med, Cancer Clin, Cardiac Toxicology, Cardiovasc Pharmacol, Fed Proc, Mot Pharmacol, New Engl, Raven Press
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