Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.
| |||||||||||||||
Book Description
Editorial Reviews
Review
"This book is an elegant survey of primate and nonprimate models for the most important of the CNS diseases, examining the prospects of treatment from various (slightly) promising drug therapies to the newest forms of fetal-tissue grafting. But more than that, the editors have compiled a paradigmatic study on the critical need for animal experimentation for the elucidation and treatment of human disease. Each chapter points out how animal models provided the only nonsuperficial insight available on various CNS syndromes, and perhaps equally important, how animals served as models for verification of theories and as test subjects for potential treatments. "- Modern Drug Discovery
"...the contributions contained in this monograph represent a serious attempt by many of the most important researchers in neuroscience to critically assess the most useful animal models in development today... this is an excellent volume which will be an essential reading for all experimental neuropharmacologists and a constant source of reference to both clinical and basic psychopharmacologists. The editors are to be congratulated for gathering together such an authoritative group of authors who have explained their research interests in an easily accessible way." - Human Phychopharmacology
"...the contributions contained in this monograph represent a serious attempt by many of the most important researchers in neuroscience to critically assess the most useful animal models in development today... this is an excellent volume which will be an essential reading for all experimental neuropharmacologists and a constant source of reference to both clinical and basic psychopharmacologists. The editors are to be congratulated for gathering together such an authoritative group of authors who have explained their research interests in an easily accessible way." - Human Phychopharmacology
From the Back Cover
In Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic, prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases, as well as their advantages and limitations. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke.
Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.
Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.
Product Details
Would you like to update product info or give feedback on images?
|
Customer Reviews
|
Share your thoughts with other customers:
|
||||||||||||||||||||||
|
Most Helpful Customer Reviews
5.0 out of 5 stars
A book of animal models for someone working in CNS diseases,
By Laoma (San Diego, CA USA) - See all my reviews
Amazon Verified Purchase(What's this?)
This review is from: Central Nervous System Diseases (Contemporary Neuroscience) (Hardcover)
I recently bought Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic (Contemporary Neuroscience series, 2000 Humana Press Inc.) from Better World Books. The most interesting sections of the book focus on the animal models most commonly used in areas of CNS diseases, which provied practical information, detailed examinations of their advantages and limitations as well. I believe it's a very good ref book for someone working in drug discovery targeting for CNS diseases.
Share your thoughts with other customers: Create your own review
|
|
Inside This Book
(learn more)
First Sentence:
It has been roughly 20 yr since the empirical foundation supporting the cholinergic hypothesis was first established. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
forebrain cholinergic degeneration, nonmnemonic variables, dyskinesia index, nonimmunosuppressive immunophilin ligand, overall asymmetry score, noncholinergic striatal neurons, rigid indentation, hypertensive monkeys, receptor knockdown, senescent monkeys, recent episodic memory, rodent tasks, contusion core, automated test apparatus, bilateral craniotomy, indentation models, fetal striatal transplants, spontaneous abnormal movements, striatal implants, ipsilateral forelimb, ischemic animals, axotomized septal neurons, body swing test, delayed recognition span test, rodent paradigms Key Phrases - Capitalized Phrases (CAPs): (learn more)
Brain Res, New York, Raven Press, Central Nervous System Diseases Edited, Humana Press Inc, Trends Neurosci, Academic Press, Life Sci, Acta Neuropathol, Operant Analysis of Striatal Dysfunction, Normal Normal, Oxford University Press, Plenum Press, Acta Physiol, Blood Flow Metab, Behavioral Outcome Measures, Primate Models of Huntington's Disease, Trophic Factor Knockout Model, United States, Dopamine-Depleted Marmoset, Aging Res, Boca Raton, Rodent Ischemia Models, Acta Neurochir, Brain Pathol New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
It has been roughly 20 yr since the empirical foundation supporting the cholinergic hypothesis was first established. Read the first page Key Phrases - Statistically Improbable Phrases (SIPs): (learn more)
forebrain cholinergic degeneration, nonmnemonic variables, dyskinesia index, nonimmunosuppressive immunophilin ligand, overall asymmetry score, noncholinergic striatal neurons, rigid indentation, hypertensive monkeys, receptor knockdown, senescent monkeys, recent episodic memory, rodent tasks, contusion core, automated test apparatus, bilateral craniotomy, indentation models, fetal striatal transplants, spontaneous abnormal movements, striatal implants, ipsilateral forelimb, ischemic animals, axotomized septal neurons, body swing test, delayed recognition span test, rodent paradigms Key Phrases - Capitalized Phrases (CAPs): (learn more)
Brain Res, New York, Raven Press, Central Nervous System Diseases Edited, Humana Press Inc, Trends Neurosci, Academic Press, Life Sci, Acta Neuropathol, Operant Analysis of Striatal Dysfunction, Normal Normal, Oxford University Press, Plenum Press, Acta Physiol, Blood Flow Metab, Behavioral Outcome Measures, Primate Models of Huntington's Disease, Trophic Factor Knockout Model, United States, Dopamine-Depleted Marmoset, Aging Res, Boca Raton, Rodent Ischemia Models, Acta Neurochir, Brain Pathol New!
Books on Related Topics | Concordance | Text Stats Browse Sample Pages:
Front Cover | Table of Contents | First Pages | Index | Back Cover | Surprise Me!
Citations (learn more)
This book cites 58
books:
See all 58 books this book cites
8
books
cite this book:
See all 8 books citing this book
- Cerebral Cortex: Volume 8A: Comparative Structure and Evolution of Cerebral Cortex, Part I by Edward G. Jones on page 76, page 424, and page 503
- Function & Dysfunction Basal Ganglia (PERGAMON STUDIES IN NEUROSCIENCE) by A. J. Franks on page 184, and page 471
- Central Nervous System Trauma: Research Techniques (Membrane Linked Diseases) by S. Tsuyoshi Ohnishi on page 384, and page 385
- Dopamine Receptors (Receptor Biochemistry and Methodology) by Ian Creese on page 209, and page 219
- Animal Models of Dementia: A Synaptic Neurochemical Perspective (Neurology and Neurobiology) by Joseph T. Coyle on page 40, and page 86
See all 58 books this book cites
- The Neuronal Environment: Brain Homeostasis in Health and Disease (Contemporary Neuroscience) by Wolfgang Walz in Front Matter
- Neuroglia in the Aging Brain (Contemporary Neuroscience) by Jean de Vellis in Front Matter
- Pathogenesis of Neurodegenerative Disorders (Contemporary Neuroscience) by Mark P. Mattson in Front Matter
- Neuroinflammation: Mechanisms and Management (Contemporary Neuroscience) by Paul L. Wood in Front Matter
- Cerebral Signal Transduction: From First to Fourth Messengers (Contemporary Neuroscience) by Maarten E. A. Reith in Front Matter
See all 8 books citing this book
Books on Related Topics
(learn more)
|
Tags Customers Associate with This Product(What's this?)Click on a tag to find related items, discussions, and people.
|
Sell a Digital Version of This Book in the Kindle Store
If you are a publisher or author and hold the digital rights to a book, you can sell a digital version of it in our Kindle Store.
Learn more
Customer Discussions
|
This product's forum
Active discussions in related forums
Search Customer Discussions
|
Related forums
|
